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Table 2 Baseline scores and outcome comparisons, stratified by SF-36 scales.

From: Assessing the order of magnitude of outcomes in single-arm cohorts through systematic comparison with corresponding cohorts: An example from the AMOS study

SF-36 scale

Baseline

Follow-up

 

AMOS patients (N = 392 patients in 5 cohorts)

Corresponding cohorts (N = 552 cohorts)

Outcome differences (N = 552 comparisons)

 

Mean *

SD *

Median *

N

Mean **

SD **

Median **

Mean ***

SD ***

25-per ***

Median ***

75-per ***

Physical Function

72.8

23.8

80.0

62

65.1

19.2

68.6

0.6

9.4

-2.0

2.0

4.4

Role Physical

37.4

38.5

25.0

59

40.0

18.3

43.4

4.1

14.1

-6.3

5.0

12.4

Role Emotional

42.4

41.5

33.3

59

59.2

16.6

62.2

-0.2

11.3

-7.5

-2.0

7.7

Social Functioning

54.8

25.1

50.0

66

61.0

12.9

60.7

2.6

9.2

-2.8

2.0

8.8

Mental Health

49.3

20.9

48.0

62

61.9

10.9

64.0

2.0

6.7

-0.9

2.2

6.4

Bodily Pain

48.8

28.1

41.0

64

45.8

15.5

44.8

2.7

10.0

-1.7

2.8

9.2

Vitality

34.3

18.0

35.0

60

45.6

9.6

47.4

3.4

6.9

-1.0

3.9

8.7

General Health

48.3

19.9

47.0

63

60.3

10.2

60.3

2.9

5.4

-1.3

4.0

6.9

Physical Component

41.7

10.2

41.3

27

37.3

7.6

37.7

1.5

3.9

-0.3

2.4

3.9

Mental Component

35.6

12.7

34.0

30

40.4

7.7

42.4

0.3

5.0

-3.6

-0.5

3.7

  1. *of patients. **of cohorts. ***of differences. N: Number of cohorts. 25-per: 25-percentile. 75-per: 75-percentile. Each outcome difference refers to one SF-36 scale at the last evaluable follow-up of the corresponding cohort: Mean difference from baseline in AMOS cohort minus mean difference from baseline in corresponding cohort. A positive difference indicates that AMOS cohorts show larger improvements than corresponding cohorts.