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Table 1 Breakdown of retrieved trials by Therapeutic Area

From: The use of interim data and Data Monitoring Committee recommendations in randomized controlled trial reports: frequency, implications and potential sources of bias

Therapeutic Area

Total number of trials retrieved in search

Trials reporting interim analysis (with or without specification of a DMC)

Trials identified as having extended use of interim data or DMC recommendations with the potential to introduce bias

Total (N)

1772

586

28

Cardiovascular Disease (CVD)

494

209

11

Oncology (ONC)

387

136

11

Infection (INF)

271

93

2

Pediatrics (PED)

71

22

0

Obstetrics & Gynecology (OBGYN)

43

20

2

Neurology (NEURO)

50

17

1

Other

456

89

1