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Table 1 Breakdown of retrieved trials by Therapeutic Area

From: The use of interim data and Data Monitoring Committee recommendations in randomized controlled trial reports: frequency, implications and potential sources of bias

Therapeutic Area Total number of trials retrieved in search Trials reporting interim analysis (with or without specification of a DMC) Trials identified as having extended use of interim data or DMC recommendations with the potential to introduce bias
Total (N) 1772 586 28
Cardiovascular Disease (CVD) 494 209 11
Oncology (ONC) 387 136 11
Infection (INF) 271 93 2
Pediatrics (PED) 71 22 0
Obstetrics & Gynecology (OBGYN) 43 20 2
Neurology (NEURO) 50 17 1
Other 456 89 1