Reporting of Human Genome Epidemiology (HuGE) association studies: An empirical assessment

Table 3 Reporting characteristics of population stratification for 315 randomly selected HuGE articles (2001–2003)

Reporting characteristic	Count	Percent
Explicitly stated that all study participants were drawn from the same ethnic population
Unclear	130	41.3
Stated	185	58.7
Analysis conducted by using different ethnic groups
No	285	90.5
Yes	30	9.5
If different ethnic groups were included, how was ethnicity treated in the analysis (n = 30)
Stratified by or adjusted for ethnic groups	23	76.7
Pooled ethnic groups together	2	6.7
Unclear	5	16.6
Reported that unlinked genetic markers were used to identify population stratification
No	313	99.4
Yes	2	0.6
Reported that cases and controls were drawn from the same population in regards to geography (n = 227)
No	79	34.8
Yes	148	65.2
Reported that cases and controls were drawn from the same population in regards to the clinical population (n = 227)
No	180	79.3
Yes	47	20.7
Reported that cases and controls were drawn from the same population in regards to the general population (n = 227)
No	167	73.6
Yes	60	26.4
Reported unclear or no information regarding the population from which cases and controls were drawn (n = 227)
No	142	62.6
Yes	85	37.4

ISSN: 1471-2288