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Table 4 Reporting characteristics of the analytic methodology and study inferences for 315 randomly selected HuGE articles (2001–2003)

From: Reporting of Human Genome Epidemiology (HuGE) association studies: An empirical assessment

Reporting characteristic Count Percent
Reported that all genetic variants were examined for Hardy-Weinberg equilibrium   
   No 164 52.1
   Yes 151 47.9
If Hardy-Weinberg equilibrium was reported, did any polymorphism reportedly fail Hardy-Weinberg equilibrium (n = 151)   
   No 141 93.4
   Yes 10 6.6
Summary data reported on all genetic variants of interest for all outcomes   
   No 41 13.0
   Yes 274 87.0
Reported that analyses were conducted by using allele-based genetic comparisons   
   No 143 45.4
   Yes 172 54.6
Reported that analyses were conducted by using genotype-based genetic comparisons   
   No 45 14.3
   Yes 270 85.7
If the analyses were conducted by using genotypes, were selected comparisons or all possible comparisons assessed (n = 270)   
   All possible 214 79.3
   Selected 56 20.7
Justifications given for the selection of specific genetic comparisons (n = 56)   
   No 33 58.9
   Yes 23 41.1
Adjustment for multiple comparisons used   
   No 276 87.6
   Yes 39 12.4
If an adjustment for multiple comparisons was used, type of adjustment was (n = 40, one article used two methods)   
   Bonferroni 28 70.0
   Fischer's post hoc 1 2.5
   Monte Carlo simulations 1 2.5
   Scheffe's test 2 5.0
   Tukey's test 3 7.5
   Unknown 5 12.5
Authors discussed the public health, medical, or clinical implications of their findings   
   No 193 61.3
   Yes (any mention) 122 38.7
Authors stated that this is the first study on the specific issue   
   No 266 84.4
   Yes 49 15.6
Clear reference made to the first study on the specific issue (n = 266)   
   No 243 91.4
   Yes 23 8.6
Clear reference made to a systematic review   
   No 297 94.3
   Yes 18 5.7
Clear reference made to a non-systematic review   
   No 309 98.1
   Yes 6 1.9