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Table 6 Reporting characteristics for the analysis of interacting environmental factors for randomly selected HuGE articles (2001–2003)

From: Reporting of Human Genome Epidemiology (HuGE) association studies: An empirical assessment

Reporting characteristic Count* Percent
Number of environmental factors assessed in gene-environment interactions   
   1 34 70.8
   2 10 20.8
   >= 3 4 8.4
Potential for misclassification of the environmental factors   
   No 7 14.6
   Unclear 4 8.3
   Yes 37 77.1
Provided a description of possible error in the measurement of the environmental factor   
   No 45 93.8
   Yes 3 6.2
Use of dose-depending models   
   No 45 93.8
   Yes 3 6.2
Reported that the evaluation of the genetic test was blind to the environmental factor   
   Blind 0 0.0
   Unclear 48 100.0
Reported that the evaluation of the environmental factor was blind to the genetic test   
   Blind 0 0.0
   Unclear 48 100.0
If gene-environmental interactions were assessed, was risk quantified as an odds ratio or risk ratio   
   No 22 45.8
   Yes 26 54.2
If gene-environmental interactions were assessed, was risk quantified as an absolute difference   
   No 48 100.0
   Yes 0 0.0
If gene-environmental interactions were assessed, was risk quantified as an attributable fraction   
   No 48 100.0
   Yes 0 0.0
Claim of a statistically significant gene-environmental interaction   
   No 34 70.8
   Yes 14 29.2
  1. * limited to the 48 studies that addressed at least 1 environmental factor