Negative pressure wound therapy: Potential publication bias caused by lack of access to unpublished study results data

Peinemann, Frank; McGauran, Natalie; Sauerland, Stefan; Lange, Stefan

doi:10.1186/1471-2288-8-4

Table 4 Search results for randomised controlled trials on negative pressure wound therapy* (Status: December 2006)

From: Negative pressure wound therapy: Potential publication bias caused by lack of access to unpublished study results data

Study status	No.	Abstract	Information source for abstract	Sponsor (ID^†)	Reply to inquiry to sponsor or author	Patients planned^‡	Patients analysed^§	Results data available	Full-text publication available^\|\|
Completed
	1	Vuerstaek [74]	WUWHS 2004	KCI (VAC VLU)	KCI	-	60	Yes^¶	Vuerstaek 2006 [23]
	2	No abstract	-	Unclear	-	-	60	Yes^¶	Llanos 2006 [25]
	3	Obdeijn [75]	WUWHS 2004	KCI (No ID)	KCI	-	65	Yes^¶	Braakenburg 2006 [21]
	4	Payne [76]	WUWHS 2004	KCI (VAC 2001–07)	KCI; author	-	162	Yes^#	Armstrong 2005 [22]
	5	Moues [77]	WUWHS 2004	KCI (PMID 14974959)	KCI	-	54	Yes^#	Moues 2004 [20]
	6	Heath [78]	The Cochrane Library	KCI (PMID 15468399)	KCI; author	-	20	Yes^#	Moisidis 2004 [18]
	7	No abstract	-	KCI (PMID 14534844)	KCI	-	6	Yes^#	Eginton 2003 [17]
	8	No abstract	-	KCI (PMID 12625392)	KCI	-	22	Yes^#	Wanner 2003 [24]
	9	Joseph [79]	The Cochrane Library	KCI (No ID)	KCI	-	24	Yes^#	Joseph 2000 [19]
	10	Adams [26]	NRR	Unclear	No reply	Unclear	Unclear	No	No
	11	Fryer [27]	ClinicalTrials.gov	Unclear	No reply	120	Unclear	No	No
	12	McCarthy [28]	NRR	Unclear	Author **	160	Unclear	No	No
	13	Walker [29]	NRR	Unclear	No reply	48	Unclear	No	No
*Subtotal*	13					328	473
Discontinued
	14	No abstract	-	KCI (PMID 12142596)	KCI	-	22	Yes^#	Interim results: Ford 2002 [30]
	15	No abstract	KCI	KCI (VAC 2001–02)	KCI	214	-	No	No
	16	Bayer [31]	WUWHS 2004	KCI (VAC 2002–09)	KCI	116	-	No	No
	17	Greer [33]	The Cochrane Library	KCI (No ID)	KCI	^†† 80	-	No	No
	18	Orgill [34]	WUWHS 2004	KCI (VAC 2002–10)	KCI	116	-	No	No
	19	Stannard [35]	WUWHS 2004	KCI (VAC 2001–06)	KCI; author	300	-	No	No
*Subtotal*	6					826	22
Ongoing
	20	Armstrong [36]	WUWHS 2004	KCI (VAC 2001–08)	KCI; author	206	-	-	No
	21	McCarthy [37]	ClinicalTrials.gov	Unclear	No reply	30	-	-	No
	22	Molnar [38]	WUWHS 2004	KCI (VAC 2001–00)	KCI	50	-	-	No
	23	Niezgoda [39]	WUWHS 2004	KCI (VAC 2001–01)	KCI	214	-	-	No
	24	Stannard [40]	WUWHS 2004	KCI (VAC 2001–04)	KCI; author	258	(44)	Yes^¶	Interim results: Stannard 2006 [80]
	25	Stannard [41]	WUWHS 2004	KCI (VAC 2001–05)	KCI; author	348	(44)	Yes^¶	Interim results: Stannard 2006 [80]
*Subtotal*	6					1106	(88)
Unclear
	26	Foo [42]	WUWHS 2004	Unclear	No reply	Unclear	-	No	No
	27	Gupta [43]	WHS 2001	Unclear	No reply	Unclear	-	No	No
	28	Lantis [44]	WUWHS 2004	Unclear	No reply	Unclear	-	No	No
*Subtotal*	3					Unclear
Total (all trials)	28					2260	495

* Not classified by IQWiG as an RCT on NPWT (in contrast to other systematic reviews): McCallon 2000 [69]; Genecov 1998 [70]; Buttenschoen 2001 [81]; Jeschke 2004 [82].
† The PubMed ID number, when available, is used by KCI as the study ID for published RCTs.
‡ Number of patients planned in unpublished and ongoing studies as stated in abstracts and personal communications.
§ Number of patients analysed in published studies.
|| Full-text publication of interim or final results (any study status).
¶ Results considered in the IQWiG rapid report.
# Results considered in the IQWiG systematic review.
** The author replied to IQWiG's first request for information and stated that the trial was ongoing. However, according to information provided by the NRR (accessed on 04 Feb 2007), this trial has since been completed. A second query was not answered.
†† According to KCI, 16 patients were enrolled in this trial.
ID: Identification code; NRR: National Research Register; PMID: PubMed Identification Code; VLU: venous leg ulcer; WHS: Wound Healing Society; WUWHS: World Union of Wound Healing Societies.

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ISSN: 1471-2288

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