TY - JOUR AU - Wittkop, Linda AU - Commenges, Daniel AU - Pellegrin, Isabelle AU - Breilh, Dominique AU - Neau, Didier AU - Lacoste, Denis AU - Pellegrin, Jean-Luc AU - Chêne, Geneviève AU - Dabis, François AU - Thiébaut, Rodolphe PY - 2008 DA - 2008/10/22 TI - Alternative methods to analyse the impact of HIV mutations on virological response to antiviral therapy JO - BMC Medical Research Methodology SP - 68 VL - 8 IS - 1 AB - Principal component analysis (PCA) and partial least square (PLS) regression may be useful to summarize the HIV genotypic information. Without pre-selection each mutation presented in at least one patient is considered with a different weight. We compared these two strategies with the construction of a usual genotypic score. SN - 1471-2288 UR - https://doi.org/10.1186/1471-2288-8-68 DO - 10.1186/1471-2288-8-68 ID - Wittkop2008 ER -