Table 1 Subgroup analysis of the sensitivity, specificity and likelihood ratios of the Papanicolaou smear test
Clinical reading (n = 1781) | Optimized interpretation (n = 1777) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Variables† | n (%) | Disease prevalence n (%) | Sensitivity % | Specificity % | Positive likelihood ratio | Negative likelihood ratio | Sensitivity % | Specificity % | Positive likelihood ratio | Negative likelihood ratio |
HPV test | ||||||||||
Positive | 537 (30) | 282 (53) | 95 | 76 | 4.02 | 0.07 | 92 | 76 | 3.93 | 0.10 |
Negative | 1244 (70) | 73 (6) | 64 | 93 | 9.31 | 0.38 | 64 | 93 | 8.85 | 0.38 |
Study setting | ||||||||||
Screening | 1320 (74) | 70 (5) | 70 | 94 | 12.32 | 0.32 | 75 | 92 | 8.96 | 0.27 |
Referral clinic | 461 (26) | 285 (62) | 93 | 60 | 2.34 | 0.12 | 89 | 77 | 3.90 | 0.14 |
Age | ||||||||||
<35 years | 981 (55) | 158 (16) | 89 | 92 | 11.66 | 0.12 | 83 | 91 | 9.44 | 0.19 |
≥ 35 years | 800 (45) | 197 (25) | 88 | 87 | 6.79 | 0.14 | 89 | 88 | 7.37 | 0.12 |
Current smoking | ||||||||||
Yes | 602 (34) | 161 (27) | 90 | 88 | 7.22 | 0.11 | 87 | 89 | 7.67 | 0.15 |
No | 1161 (66) | 188 (16) | 87 | 91 | 9.98 | 0.14 | 87 | 90 | 8.94 | 0.15 |
European origin | ||||||||||
Yes | 1623 (91) | 312 (19) | 88 | 91 | 9.71 | 0.13 | 87 | 90 | 8.81 | 0.15 |
No | 158 (9) | 43 (27) | 91 | 81 | 4.74 | 0.11 | 83 | 86 | 5.99 | 0.19 |
Educational level | ||||||||||
< Higher | 1063 (60) | 227 (21) | 88 | 87 | 7.15 | 0.14 | 87 | 88 | 7.31 | 0.15 |
≥ Higher | 709 (40) | 128 (18) | 89 | 93 | 14.38 | 0.12 | 86 | 92 | 11.06 | 0.15 |
Postmenopausal | ||||||||||
Yes | 174 (10) | 44 (25) | 86 | 88 | 7.49 | 0.15 | 93 | 91 | 10.09 | 0.08 |
No | 1607 (90) | 311 (19) | 89 | 90 | 9.13 | 0.12 | 85 | 90 | 8.31 | 0.16 |
Contraception | ||||||||||
None | 640 (36) | 127 (20) | 89 | 89 | 8.30 | 0.12 | 87 | 90 | 8.93 | 0.14 |
Combined oral pill | 905 (51) | 173 (19) | 87 | 91 | 9.26 | 0.14 | 83 | 90 | 8.50 | 0.19 |
Others | 236 (13) | 55 (23) | 91 | 91 | 9.68 | 0.10 | 96 | 87 | 7.27 | 0.04 |