Skip to main content

Table 2 Summary of significance tests for combining different estimates from m imputed datasets after MI

From: Combining estimates of interest in prognostic modelling studies after multiple imputation: current practice and guidelines

Estimate

F

Test statistic

Degrees of freedom (df)

Relative increase in variance ( r )

A) Scalar

F 1, v

, H0: Q = Q 0

v = (m - 1)(1 + r -1)2

B) Multivariate

H0:Q = Q 0,

k = number of parameters

where a = k(m - 1)

C)

χ 2 statistics

w 1,..., w m

k = df associated with χ 2 tests

D) Likelihood Ratio χ 2 statistics

w L1,..., w Lm

k = number of parameters in fitted model

where a = k(m - 1)

  1. KEY: F = value from the F-distribution, which the test statistic is compared to.
  2. = average of the m imputed data estimates.
  3. = within imputation variance.
  4. B = between imputation variance.
  5. T = total variance for the combined MI estimate.
  6. w j , j = 1,..., m = χ 2 statistics associated with testing the null hypothesis H o : Q = Q o on each imputed dataset, such that the significance level for the j thimputed dataset is P{ > w j }, where is the χ 2 value with k degrees of freedom (Rubin 1987).
  7. = average of the repeated χ 2 statistics.
  8. = average of the m likelihood ratio statistics, w L1,..., w Lm , evaluated using the average MI parameter estimates and the average of the estimates from a model fitted subject to the null hypothesis.