|
Number of patientsN0
|
---|
θ
|
d=2,p=0.2
|
d=8,p=0.5
|
---|
0
|
160
|
184
|
0.1
|
204
|
226
|
0.2
|
252
|
274
|
0.3
|
296
|
320
|
0.4
|
340
|
366
|
0.5
|
380
|
422
|
- The simulation algorithm was applied to derive the number of individuals required for 80% power applying the robust two-sided Wald test at a 5% significance level for different frailty variances θ and risk-free intervals of length d (weeks) following an event with probability p. Each result was derived from 10000 simulation runs.