Simulating recurrent event data with hazard functions defined on a total time scale

Table 1 Sample size calculation results

The simulation algorithm was applied to derive the number of individuals required for 80% power applying the robust two-sided Wald test at a 5% significance level for different frailty variances θ and risk-free intervals of length d (weeks) following an event with probability p. Each result was derived from 10000 simulation runs.

ISSN: 1471-2288