Applicative example on primary biliary cirrhosis. Panel A. Estimated survival curve with 95% confidence bands. Panel B. Histogram for the MAYOSCORE5 prognostic score. Panel C. ROC curve for the MAYOSCORE5 prognostic score with the three objective functions: the Youden index J(ĉJ) represented by the thick line segment, the concordance probability CZ(ĉCZ) represented by the area of the dotted rectangle and the distance from the (0,1) corner ER(ĉER) represented by the thin line segment. The 95% elliptic asymptotic confidence interval of (FPF(ĉ), TPF(ĉ)) is also represented.