From: Validation of death prediction after breast cancer relapses using joint models
Joint model | Cox landmark | |||||
---|---|---|---|---|---|---|
For recurrent events | For death | For death | ||||
Variable | HR | (95% CI) | HR | (95% CI) | HR | (95% CI) |
Age | ||||||
[40−55] vs. >55 | 1.17 | (0.91-1.51) | 0.31 | (0.16-0.60) | 0.56 | (0.41-0.76) |
≤40 vs. >55 | 2.41 | (1.73-3.37) | 1.57 | (0.73-3.38) | 0.54 | (0.31-0.92) |
Peritumoural vascular involvement | 1.61 | (1.26-2.06) | 4.74 | (2.54-8.85) | 1.04 | (0.76-1.43) |
Tumour size (>20 mm vs. ≤20 mm) | 1.95 | (1.52-2.50) | 6.21 | (2.99-12.86) | 1.20 | (0.88-1.65) |
Nodal involvement | 1.84 | (1.44-2.36) | 4.89 | (2.47-9.67) | 1.95 | (1.45-2.60) |
Grade | ||||||
II vs. I | 2.18 | (1.57-3.01) | 7.48 | (2.71-20.66) | 1.07 | (0.75-1.52) |
III vs. I | 3.09 | (2.16-4.41) | 44.33 | (15.61-125.93) | 1.25 | (0.83-1.88) |
Recurrences before t=5 years | ||||||
One previous recurrence | 7.18 | (5.25-9.83) | ||||
Two previous recurrences | 6.94 | (3.05-15.83) | ||||
θ=var(ui) | 1.07 | (se=0.06) | ||||
α | 4.45 | (se=0.33) | ||||
LCV | 1.19 | 0.93 |