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Table 2 Joint and Landmark Cox models estimations on the French cohort (n=1067 patients, 427 recurrent events)

From: Validation of death prediction after breast cancer relapses using joint models

 

Joint model

Cox landmark

 

For recurrent events

For death

For death

Variable

HR

(95% CI)

HR

(95% CI)

HR

(95% CI)

Age

[40−55] vs. >55

1.17

(0.91-1.51)

0.31

(0.16-0.60)

0.56

(0.41-0.76)

≤40 vs. >55

2.41

(1.73-3.37)

1.57

(0.73-3.38)

0.54

(0.31-0.92)

Peritumoural vascular involvement

1.61

(1.26-2.06)

4.74

(2.54-8.85)

1.04

(0.76-1.43)

Tumour size (>20 mm vs. ≤20 mm)

1.95

(1.52-2.50)

6.21

(2.99-12.86)

1.20

(0.88-1.65)

Nodal involvement

1.84

(1.44-2.36)

4.89

(2.47-9.67)

1.95

(1.45-2.60)

Grade

II vs. I

2.18

(1.57-3.01)

7.48

(2.71-20.66)

1.07

(0.75-1.52)

III vs. I

3.09

(2.16-4.41)

44.33

(15.61-125.93)

1.25

(0.83-1.88)

Recurrences before t=5 years

One previous recurrence

    

7.18

(5.25-9.83)

Two previous recurrences

    

6.94

(3.05-15.83)

θ=var(ui)

1.07

(se=0.06)

    

α

4.45

(se=0.33)

    

LCV

1.19

   

0.93

 
  1. HR: Hazard ratio; CI: Confidence interval; LCV: Likelihood cross-validation criterion; Cox Landmark at time t = 5 years.