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Table 3 Measured and published sensitivity and specificity for each test in the integrated dataset before imputation, mean and 95 % CIs

From: A holistic comparative analysis of diagnostic tests for urothelial carcinoma: a study of Cxbladder Detect, UroVysion® FISH, NMP22® and cytology based on imputation of multiple datasets

 

Measured

Published

 

Sensitivity, % (95 % CI)

Specificity, % (95 % CI)

Sensitivity, % (95 % CI)

Specificity, % (95 % CI)

Cytology

45.5 (40.6–50.4)

96.3 (94.5–97.9)

56.1 (43.3–68.3) [18]

94.5 (91.9–96.5) [18]

NMP22

44.9 (37.4–52.3)

89.0 (86.5–91.5)

50.0 (37.4–62.6) [18]

88.0 (84.6–91.0) [18]

FISH

40.0 (22.7–52.3)

87.3 (83.7–91.6)

72 (69–75) [22]

83 (82–85) [22]

   

61.9 [23]

89.7 [23]

   

18 [24]

90 [24]

Cxbladder Detect

79.5 (71.1–87.8)

82.2 (79.2–85.0)

81.8 [18]

85.1 (fixed) [18]