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Table 5 Sensitivity and specificity of tests measured on the integrated, imputed dataset using different imputation methods

From: A holistic comparative analysis of diagnostic tests for urothelial carcinoma: a study of Cxbladder Detect, UroVysion® FISH, NMP22® and cytology based on imputation of multiple datasets

  Supervised imputation Unsupervised imputation
  Sensitivity, % Specificity, % Sensitivity, % Specificity, %
3NN  
Cytology 44.94 96.35 44.94 96.35
NMP22 41.57 88.82 41.57 88.94
FISH 32.58 85.24 38.20 85.95
Cxbladder Detect 80.90 82.12 77.53 79.76
5NN  
Cytology 44.94 96.35 44.94 96.35
NMP22 43.82 90.26 39.33 90.24
FISH 29.21 91.90 31.46 91.55
Cxbladder Detect 80.90 83.80 77.53 80.47
10NN  
Cytology 44.94 96.49 44.94 96.35
NMP22 43.82 90.59 39.33 90.35
FISH 29.21 91.07 23.60 90.00
Cxbladder Detect 80.90 85.53 78.65 82.59
MLR  
Cytology 44.94 96.35 44.94 96.56
NMP22 42.70 90.82 39.33 90.82
FISH 47.19 93.69 47.19 93.33
Cxbladder Detect 80.90 77.29 77.53 84.71
MLP  
Cytology 44.94 96.35 44.94 96.35
NMP22 39.33 90.82 39.33 90.82
FISH 49.44 93.81 47.19 93.33
Cxbladder Detect 78.65 85.18 77.53 84.71