From: Statistical inference for extended or shortened phase II studies based on Simon’s two-stage designs
Width | Coverage | Actual power | ||||
---|---|---|---|---|---|---|
π true | LR | KC | LR | KC | LR | KC |
Design 1 (0.2 vs 0.4) | ||||||
(r 1,n 1,r2,n)=(3,13,12,43) | ||||||
0.1 | .265 | .270 | 99.7 | 96.6 | 0.1 | 0.0 |
0.2 | .287 | .292 | 93.2 | 94.5 | 4.6 | 8.4 |
0.3 | .278 | .275 | 94.2 | 94.6 | 40.4 | 47.8 |
0.4 | .276 | .270 | 91.3 | 93.4 | 81.3 | 86.2 |
0.5 | .278 | .277 | 89.3 | 87.8 | 97.3 | 97.5 |
0.6 | .270 | .281 | 91.1 | 89.4 | 99.9 | 99.8 |
0.7 | .250 | .260 | 90.2 | 87.7 | 100.0 | 100.0 |
0.8 | .218 | .221 | 91.4 | 88.6 | 100.0 | 100.0 |
Design 2 (0.3 vs 0.5) | ||||||
(r 1,n 1,r 2,n)=(5,15,18,46) | ||||||
0.1 | .239 | .239 | 98.6 | 98.6 | 0.0 | 0.0 |
0.2 | .298 | .302 | 92.2 | 90.5 | 0.2 | 0.2 |
0.3 | .299 | .311 | 94.4 | 93.6 | 2.9 | 6.4 |
0.4 | .273 | .280 | 91.8 | 92.9 | 34.6 | 50.1 |
0.5 | .256 | .254 | 90.1 | 93.2 | 79.1 | 87.0 |
0.6 | .246 | .241 | 87.9 | 88.2 | 98.0 | 99.1 |
0.7 | .228 | .232 | 90.1 | 88.9 | 100.0 | 100.0 |
0.8 | .198 | .211 | 91.5 | 89.6 | 100.0 | 100.0 |
Design 3 (0.4 vs 0.6) | ||||||
(r 1,n 1,r 2,n)=(7,16,23,46) | ||||||
0.1 | .265 | .265 | 97.0 | 97.0 | 0.0 | 0.0 |
0.2 | .337 | .338 | 98.3 | 98.0 | 0.5 | 0.0 |
0.3 | .354 | .365 | 95.1 | 95.4 | 0.9 | 0.2 |
0.4 | .328 | .347 | 93.6 | 94.9 | 5.4 | 7.0 |
0.5 | .289 | .298 | 89.2 | 90.3 | 37.4 | 45.7 |
0.6 | .258 | .256 | 92.8 | 95.0 | 83.4 | 85.6 |
0.7 | .235 | .231 | 90.9 | 90.7 | 98.9 | 98.8 |
0.8 | .206 | .205 | 90.2 | 88.9 | 100.0 | 100.0 |
Design 4 (0.5 vs 0.7) | ||||||
(r 1,n 1,r 2,n)=(8,15,26,43) | ||||||
0.1 | .246 | .246 | 99.1 | 99.1 | 0.0 | 0.0 |
0.2 | .310 | .310 | 95.7 | 95.7 | 0.0 | 0.0 |
0.3 | .348 | .349 | 93.6 | 93.4 | 0.0 | 0.0 |
0.4 | .361 | .366 | 93.1 | 91.4 | 0.5 | 0.4 |
0.5 | .336 | .349 | 91.3 | 93.3 | 5.7 | 8.3 |
0.6 | .289 | .297 | 89.9 | 92.7 | 37.4 | 43.9 |
0.7 | .242 | .243 | 89.6 | 93.5 | 85.2 | 87.1 |
0.8 | .204 | .203 | 89.1 | 90.0 | 99.0 | 99.4 |