# Table 1 Simulation examples: estimated means and standard deviations (in parentheses) of the empirical Youden index J over 100 replications

n=100 n=250 n=500
Example 1
LKME 0.604 (0.0042) 0.628 (0.0019) 0.641 (0.0018)
GKME 0.572 (0.0063) 0.604 (0.0029) 0.623 (0.0023)
MMM 0.455 (0.0032) 0.470 (0.0021) 0.483 (0.0020)
MVN 0.633 (0.0018) 0.638 (0.0014) 0.647 (0.0012)
KSM 0.388 (0.0180) 0.458 (0.0104) 0.490 (0.0106)
SWM 0.555 (0.0065) 0.594 (0.0044) 0.611 (0.0035)
LR 0.628 (0.0022) 0.639 (0.0017) 0.646 (0.0017)
TREE 0.490 (0.0068) 0.525 (0.0047) 0.559 (0.0029)
Example 2
LKME 0.636 (0.0075) 0.690 (0.0025) 0.710 (0.0015)
GKME 0.612 (0.0054) 0.654 (0.0045) 0.696 (0.0016)
MMM 0.609 (0.0033) 0.622 (0.0025) 0.622 (0.0022)
MVN 0.573 (0.0065) 0.571 (0.0047) 0.563 (0.0040)
KSM 0.214 (0.0281) 0.046 (0.0164) 0.047 (0.0171)
SWM 0.447 (0.0094) 0.426 (0.0078) 0.429 (0.0065)
LR 0.648 (0.0054) 0.675 (0.0028) 0.678 (0.0025)
TREE 0.433 (0.0052) 0.512 (0.0039) 0.555 (0.0036)
Example 3
LKME 0.296 (0.0091) 0.367 (0.0053) 0.389 (0.0049)
GKME 0.511 (0.0052) 0.568 (0.0028) 0.592 (0.0022)
MMM 0.423 (0.0035) 0.434 (0.0021) 0.443 (0.0018)
MVN 0.344 (0.0050) 0.371 (0.0045) 0.377 (0.0041)
KSM 0.192 (0.0085) 0.193 (0.0084) 0.202 (0.0086)
SWM 0.370 (0.0057) 0.406 (0.0028) 0.417 (0.0025)
LR 0.307 (0.0043) 0.316 (0.0030) 0.320 (0.0026)
TREE 0.424 (0.0059) 0.477 (0.0042) 0.528 (0.0031)
Example 4
LKME 0.103 (0.0102) 0.150 (0.0098) 0.209 (0.0089)
GKME 0.529 (0.0078) 0.626 (0.0050) 0.682 (0.0028)
MMM 0.184 (0.0084) 0.227 (0.0034) 0.236 (0.0026)
MVN 0.109 (0.0071) 0.152 (0.0056) 0.189 (0.0054)
KSM 0.188 (0.0050) 0.213 (0.0035) 0.220 (0.0028)
SWM 0.255 (0.0078) 0.293 (0.0050) 0.307 (0.0039)
LR 0.002 (0.0023) 0.004 (0.0008) 0.011 (0.0007)
TREE 0.257 (0.0143) 0.364 (0.0111) 0.368 (0.0101)