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Table 2 Estimated regression coefficients (and standard error) from JPHC data

From: Synthesis of clinical prediction models under different sets of covariates with one individual patient data

  Area 1 Area 2 Area 3 Area 4 Area 5 Area 6
Sample 2121 1678 3396 859 3135 538
Incedence of stroke 109 82 132 23 142 35
Intercept -12.280 (1.394) -9.828 (1.668) -9.917 (1.225) -8.703 (2.846) -11.940 (1.367) -9.475 (3.070)
Age 0.085 (0.022) 0.095 (0.024) 0.066 (0.018) 0.022 (0.042) 0.113 (0.016) 0.126 (0.042)
Postprandial time -0.016 (0.026) -0.023 (0.041) -0.019 (0.018)    
BMI 0.001 (0.001) 0.000 (0.001) 0.000 (0.001) 0.000 (0.002) 0.000 (0.001) -0.002 (0.002)
Total cholesterol level 0.003 (0.003) -0.001 (0.003) -0.001 (0.003) -0.001 (0.006) -0.004 (0.003) -0.011 (0.006)
Blood pressure 0.027 (0.005) 0.016 (0.007) 0.028 (0.005) 0.022 (0.012) 0.020 (0.006) 0.013 (0.010)
Smoke (per day) 0.020 (0.009) 0.028 (0.010) 0.010 (0.007) 0.012 (0.019) 0.000 (0.007) -0.019 (0.021)
Diabetes 0.397 (0.504) 1.202 (0.525) 0.738 (0.362) 0.240 (1.314) 0.302 (0.314) -0.174 (1.065)
Glucose    -0.004 (0.004) 0.012 (0.006) 0.004 (0.003)  
HDL      -0.005 (0.007) 0.012 (0.014)
Triglycerides    0.001 (0.001)   0.000 (0.001) 0.001 (0.003)
AUC 67.01 68.74 67.97 65.52 69.16 68.19
Brier score 7.71 7.72 7.65 8.07 7.78 7.68
Hosmer-Lemeshow 10.91 15.78* 14.01 101.45* 54.96* 17.70*
  Area 7 Area 8 Area 9 Area 10 Proposed Conventional
Sample 1601 1731 1586 2725   
Incedence of stroke 85 90 90 52   
Intercept -9.223 (1.710) -8.413 (1.499) -10.300 (1.729) -10.500 (1.878) -10.170 (0.633) -9.408nn
Age 0.088 (0.020) 0.072 (0.018) 0.096 (0.021) 0.069 (0.020) 0.067nn 0.060n
Postprandial time -0.009 (0.024) -0.007 (0.025) -0.006 (0.019) 0.018 (0.034) 0.013 (0.011) 0.017 (0.013)
BMI -0.001 (0.001) -0.002 (0.001) -0.001 (0.001) 0.000nn 0.000nnn 0.000 (0.001)
Total cholesterol level 0.001 (0.004) 0.001 (0.003) 0.001 (0.004) -0.003 (0.005) -0.001 (0.001) 0.001 (0.002)
Blood pressure 0.011 (0.006) 0.015 (0.006) 0.015 (0.007) 0.017 (0.007) 0.017 (0.002) 0.011 (0.004)
Smoke (per day) 0.025 (0.010) 0.007 (0.010) 0.020 (0.009) 0.011 (0.010) 0.013 (0.004) 0.020 (0.006)
Diabetes 0.168 (0.455) 0.052 (0.485) 0.268 (0.490) 0.694 (0.465) 0.158 (0.180) 0.084 (0.262)
Glucose 0.009 (0.003)   0.004 (0.004) -0.001 (0.008) 0.010 (0.001) 0.014 (0.002)
HDL -0.022 (0.010) -0.001 (0.009) -0.013 (0.010) 0.005 (0.012) -0.004 (0.005) -0.008 (0.006)
Triglycerides -0.003 (0.002) -0.002 (0.002) -0.001 (0.001) 0.002 (0.002) 0.000 (0.001) 0.000 (0.001)
AUC 68.32 69.47 68.29 67.28 68.01 67.24
Brier score 7.77 7.63 7.64 8.03 7.72 7.80
Hosmer-Lemeshow 58.60* 28.70* 25.38* 186.76* 21.13* 21.17*
  1. Proposed: our proposed method; Conventional: conventional meta-analysis using only studies with a full set of covariates
  2. Area 9 is IPD
  3. *p-value of Hosmer-Lemeshow test is less than 0.05