Synthesis of clinical prediction models under different sets of covariates with one individual patient data

Yoneoka, Daisuke; Henmi, Masayuki; Sawada, Norie; Inoue, Manami

doi:10.1186/s12874-015-0087-x

BMC Medical Research Methodology

Table 2 Estimated regression coefficients (and standard error) from JPHC data

From: Synthesis of clinical prediction models under different sets of covariates with one individual patient data

	Area 1	Area 2	Area 3	Area 4	Area 5	Area 6
Sample	2121	1678	3396	859	3135	538
Incedence of stroke	109	82	132	23	142	35
Intercept	-12.280 (1.394)	-9.828 (1.668)	-9.917 (1.225)	-8.703 (2.846)	-11.940 (1.367)	-9.475 (3.070)
Age	0.085 (0.022)	0.095 (0.024)	0.066 (0.018)	0.022 (0.042)	0.113 (0.016)	0.126 (0.042)
Postprandial time	-0.016 (0.026)	-0.023 (0.041)	-0.019 (0.018)
BMI	0.001 (0.001)	0.000 (0.001)	0.000 (0.001)	0.000 (0.002)	0.000 (0.001)	-0.002 (0.002)
Total cholesterol level	0.003 (0.003)	-0.001 (0.003)	-0.001 (0.003)	-0.001 (0.006)	-0.004 (0.003)	-0.011 (0.006)
Blood pressure	0.027 (0.005)	0.016 (0.007)	0.028 (0.005)	0.022 (0.012)	0.020 (0.006)	0.013 (0.010)
Smoke (per day)	0.020 (0.009)	0.028 (0.010)	0.010 (0.007)	0.012 (0.019)	0.000 (0.007)	-0.019 (0.021)
Diabetes	0.397 (0.504)	1.202 (0.525)	0.738 (0.362)	0.240 (1.314)	0.302 (0.314)	-0.174 (1.065)
Glucose			-0.004 (0.004)	0.012 (0.006)	0.004 (0.003)
HDL					-0.005 (0.007)	0.012 (0.014)
Triglycerides			0.001 (0.001)		0.000 (0.001)	0.001 (0.003)
AUC	67.01	68.74	67.97	65.52	69.16	68.19
Brier score	7.71	7.72	7.65	8.07	7.78	7.68
Hosmer-Lemeshow	10.91	15.78*	14.01	101.45*	54.96*	17.70*
	Area 7	Area 8	Area 9	Area 10	Proposed	Conventional
Sample	1601	1731	1586	2725
Incedence of stroke	85	90	90	52
Intercept	-9.223 (1.710)	-8.413 (1.499)	-10.300 (1.729)	-10.500 (1.878)	-10.170 (0.633)	-9.408nn
Age	0.088 (0.020)	0.072 (0.018)	0.096 (0.021)	0.069 (0.020)	0.067nn	0.060n
Postprandial time	-0.009 (0.024)	-0.007 (0.025)	-0.006 (0.019)	0.018 (0.034)	0.013 (0.011)	0.017 (0.013)
BMI	-0.001 (0.001)	-0.002 (0.001)	-0.001 (0.001)	0.000nn	0.000nnn	0.000 (0.001)
Total cholesterol level	0.001 (0.004)	0.001 (0.003)	0.001 (0.004)	-0.003 (0.005)	-0.001 (0.001)	0.001 (0.002)
Blood pressure	0.011 (0.006)	0.015 (0.006)	0.015 (0.007)	0.017 (0.007)	0.017 (0.002)	0.011 (0.004)
Smoke (per day)	0.025 (0.010)	0.007 (0.010)	0.020 (0.009)	0.011 (0.010)	0.013 (0.004)	0.020 (0.006)
Diabetes	0.168 (0.455)	0.052 (0.485)	0.268 (0.490)	0.694 (0.465)	0.158 (0.180)	0.084 (0.262)
Glucose	0.009 (0.003)		0.004 (0.004)	-0.001 (0.008)	0.010 (0.001)	0.014 (0.002)
HDL	-0.022 (0.010)	-0.001 (0.009)	-0.013 (0.010)	0.005 (0.012)	-0.004 (0.005)	-0.008 (0.006)
Triglycerides	-0.003 (0.002)	-0.002 (0.002)	-0.001 (0.001)	0.002 (0.002)	0.000 (0.001)	0.000 (0.001)
AUC	68.32	69.47	68.29	67.28	68.01	67.24
Brier score	7.77	7.63	7.64	8.03	7.72	7.80
Hosmer-Lemeshow	58.60*	28.70*	25.38*	186.76*	21.13*	21.17*

Proposed: our proposed method; Conventional: conventional meta-analysis using only studies with a full set of covariates
Area 9 is IPD
^*p-value of Hosmer-Lemeshow test is less than 0.05

Back to article page

ISSN: 1471-2288

Contact us

General enquiries: journalsubmissions@springernature.com