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Table 3 Subgroup identification and analysis of 52 squamous cell carcinoma patients using a leave-one-out cross validation for five classification methods. There were 26 patients in ACT and 26 patients in OBS

From: Subgroup identification for treatment selection in biomarker adaptive design

  DLDA ASD (−1,1) ASD (−1,2) ASD (−2,1) ASD (−2,2)
Comparison 1 0.138 0.138 0.138 0.138 0.138
Comparison 2 0.07 0.125 0.149 0.428 0.114
Comparison 3 0.039 0.083 0.847 0.125 0.008
Comparison 4 1.25E-08 0.001 0.689 0.267 0.143
Comparison 5 0.697 0.697 0.938 0.791 0.034
g+ (T)a 6.79 (24) 6.71 (25) 6.71 (23) 6.71 (17) 5.21 (6)
g+ (C) 5.68 (23) 5.68 (23) 5.44 (22) 3.00 (15) 6.59 (8)
g− (T) 1.21 (2) 1.32 (1) 6.54 (3) 6.54 (9) 6.79 (20)
g− (C) 3.17 (3) 3.17 (3) 4.43 (4) 5.68 (11) 3.09 (18)
  1. Each method classified patients into 4 subgroups: g+ (T), g+ (C) g− (T) and g− (C)
  2. aMedian survival time (year) in the subgroup and the number of patients in the subgroup in parentheses