TY - JOUR AU - Burny, Claire AU - Rabilloud, Muriel AU - Golfier, François AU - Massardier, Jérôme AU - Hajri, Touria AU - Schott, Anne-Marie AU - Subtil, Fabien PY - 2016 DA - 2016/01/05 TI - Early diagnosis of gestational trophoblastic neoplasia based on trajectory classification with compartment modeling JO - BMC Medical Research Methodology SP - 3 VL - 16 IS - 1 AB - In randomized clinical trials or observational studies, it is common to collect biomarker values longitudinally on a cohort of individuals. The investigators may be interested in grouping individuals that share similar changes of biomarker values and use these groups for diagnosis or therapeutic purposes. However, most classical model-based classification methods rely mainly on empirical models such as splines or polynomials and do not reflect the physiological processes. SN - 1471-2288 UR - https://doi.org/10.1186/s12874-015-0106-y DO - 10.1186/s12874-015-0106-y ID - Burny2016 ER -