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Table 1 Statistics for three randomized trials used in examples

From: Augmenting the logrank test in the design of clinical trials in which non-proportional hazards of the treatment effect may be anticipated

Trial

n

e

HR (SE)

P LR

P Cox

P GT

P joint

P perm

P comb

GOG111

386

343

0.73 (0.08)

0.0037

0.0038

0.0061

0.00035

0.00041

0.00062

PATCH1

274

129

0.71 (0.13)

0.052

0.052

0.051

0.023

0.015

0.023

ICON7

1528

759

0.81 (0.06)

0.0041

0.0042

9×10−13

1×10−13

4×10−9

6×10−9

  1. n = number of patients, e = number of events For further details, see the text