Fig. 2
Examples of curve groups according to time to diagnosis. Example of two different curve groups: curve group ‘123’ (upper panel, gene expression values increasing with time) and curve group‘132’ (lower panel, highest gene expression value in the middle time period). In the left panels curves with the gene expression differences X g,p for 20 genes from the given curve group are plotted. For illustrational purposes, the curves have been estimated from the data using splines. In the middle panels the data X g,p for one of the 20 genes are shown with the corresponding spline-estimated curve. The points represent the differences in gene expression X g,p for each case-control pair. The mean value in each time period, \( {\overline{X}}_{g,3,s} \), \( {\overline{X}}_{g,2,s} \) and \( {\overline{X}}_{g,1,s} \), is shown in red. The right panels are similar to the middle panels except that the data points that are plotted are the mean values computed over the 20 genes in the left panel