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Table 6 P-values obtained when testing whether the curve group variables Z c,s,p are different for the strata «screen-detected and interval cancers with spread» and «screen-detected and interval cancers without spread»

From: A new statistical method for curve group analysis of longitudinal gene expression data illustrated for breast cancer in the NOWAC postgenome cohort as a proof of principle

p-value
  Genes selected based on stratum s 1 = «Screen-detected and interval cancers with spread» \( {Z}_{c,{s}_1,p} \) Genes selected based on stratum s 2 = «Screen-detected and interval cancers without spread» \( {Z}_{c,{s}_2,p} \)
Time period t 3 2 1 3 2 1
 N1 69 20 12 69 20 12
 N2 148 57 53 148 57 53
Curve group c  
 123 0.22 0.59 0.02* 0.53 0.11 0.08
 132 0.90 0.005* 0.004* 0.71 0.11 0.009*
 312 0.80 0.27 0.15 0.04* 0.009* 0.001*
 321 0.12 0.98 0.24 0.35 0.72 0.15
 231 0.26 0.45 0.78 0.34 0.38 0.23
 213 0.53 0.45 0.65 0.36 0.04* 0.08
  1. *P-values below 0.05. ‘N1’ is the number of case-control pairs in the stratum «Screening or interval with spread» in the time period t, while ‘N2’ is the number of case-control pairs in the stratum «Screening or interval without spread» in the time period t