A new statistical method for curve group analysis of longitudinal gene expression data illustrated for breast cancer in the NOWAC postgenome cohort as a proof of principle

Table 6 P-values obtained when testing whether the curve group variables Z _c,s,p are different for the strata «screen-detected and interval cancers with spread» and «screen-detected and interval cancers without spread»

p-value
	Genes selected based on stratum s ₁ = «Screen-detected and interval cancers with spread» \( {Z}_{c,{s}_1,p} \)			Genes selected based on stratum s ₂ = «Screen-detected and interval cancers without spread» \( {Z}_{c,{s}_2,p} \)
Time period t	3	2	1	3	2	1
N1	69	20	12	69	20	12
N2	148	57	53	148	57	53
Curve group c
123	0.22	0.59	0.02*	0.53	0.11	0.08
132	0.90	0.005*	0.004*	0.71	0.11	0.009*
312	0.80	0.27	0.15	0.04*	0.009*	0.001*
321	0.12	0.98	0.24	0.35	0.72	0.15
231	0.26	0.45	0.78	0.34	0.38	0.23
213	0.53	0.45	0.65	0.36	0.04*	0.08

*P-values below 0.05. ‘N1’ is the number of case-control pairs in the stratum «Screening or interval with spread» in the time period t, while ‘N2’ is the number of case-control pairs in the stratum «Screening or interval without spread» in the time period t