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Table 3 Results for comparisons of methods in estimating the difference in restricted mean survival time (rmstD) in MAC-NPC and MAC-NPC2 meta-analyses

From: Bias and precision of methods for estimating the difference in restricted mean survival time from an individual patient data meta-analysis

Meta-analysis model

Methods

MAC-NPC

MAC-NPC2

t * = 5 years

t * = 10 years

t * = 5 years

t * = 10 years

rmstD

SE

p-value

rmstD

SE

p-value

rmstD

SE

p-value

rmstD

SE

p-value

 

Naïve Kaplan-Meier

0.20

0.08

0.008

0.51

0.19

0.006

0.17

0.04

<0.001

0.54

0.11

<0.001

Random effects

Pooled Kaplan-Meier

0.17

0.11

0.106

0.49

0.28

0.081

0.20

0.05

<0.001

0.59

0.13

<0.001

Pooled Exponential

0.17

0.09

0.076

0.51

0.29

0.078

0.17

0.03

<0.001

0.55

0.11

<0.001

Peto-quintile

0.23

0.09

0.007

0.55

0.22

0.011

0.21

0.04

<0.001

0.59

0.12

<0.001

Fixed effect

Pooled Kaplan-Meier

0.20

0.07

0.005

0.52

0.18

0.004

0.18

0.04

<0.001

0.59

0.10

<0.001

Pooled Exponential

0.18

0.06

0.003

0.55

0.18

0.002

0.17

0.03

<0.001

0.56

0.09

<0.001

Peto-quintile

0.20

0.07

0.006

0.46

0.16

0.004

0.18

0.04

<0.001

0.53

0.09

<0.001

  1. MAC-NPC meta-analysis of chemotherapy in nasopharynx carcinoma, rmstD difference in restricted mean survival time, SE standard error, t * time horizon