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Table 3 Results for comparisons of methods in estimating the difference in restricted mean survival time (rmstD) in MAC-NPC and MAC-NPC2 meta-analyses

From: Bias and precision of methods for estimating the difference in restricted mean survival time from an individual patient data meta-analysis

Meta-analysis model Methods MAC-NPC MAC-NPC2
t * = 5 years t * = 10 years t * = 5 years t * = 10 years
rmstD SE p-value rmstD SE p-value rmstD SE p-value rmstD SE p-value
  Naïve Kaplan-Meier 0.20 0.08 0.008 0.51 0.19 0.006 0.17 0.04 <0.001 0.54 0.11 <0.001
Random effects Pooled Kaplan-Meier 0.17 0.11 0.106 0.49 0.28 0.081 0.20 0.05 <0.001 0.59 0.13 <0.001
Pooled Exponential 0.17 0.09 0.076 0.51 0.29 0.078 0.17 0.03 <0.001 0.55 0.11 <0.001
Peto-quintile 0.23 0.09 0.007 0.55 0.22 0.011 0.21 0.04 <0.001 0.59 0.12 <0.001
Fixed effect Pooled Kaplan-Meier 0.20 0.07 0.005 0.52 0.18 0.004 0.18 0.04 <0.001 0.59 0.10 <0.001
Pooled Exponential 0.18 0.06 0.003 0.55 0.18 0.002 0.17 0.03 <0.001 0.56 0.09 <0.001
Peto-quintile 0.20 0.07 0.006 0.46 0.16 0.004 0.18 0.04 <0.001 0.53 0.09 <0.001
  1. MAC-NPC meta-analysis of chemotherapy in nasopharynx carcinoma, rmstD difference in restricted mean survival time, SE standard error, t * time horizon