Sample size | True benefit | Posterior mean estimate biases | Enrolled sample sizes | % Early stopping | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
dB | dC | pA | pB | pC | nA | nB | nC | A | % early B | % early C | |
40 | −0.20 | 0.00 | −0.0051 | 0.0305 | −0.0063 | 36.3504 | 15.0121 | 36.3180 | 15.32 % | 96.09 % | 15.15 % |
−0.15 | 0.00 | −0.0058 | 0.0061 | −0.0057 | 36.2548 | 21.3829 | 36.3305 | 15.43 % | 79.69 % | 15.19 % | |
−0.10 | 0.00 | −0.0063 | −0.0066 | −0.0062 | 36.3540 | 27.9657 | 36.3594 | 15.20 % | 53.98 % | 15.36 % | |
−0.05 | 0.00 | −0.0056 | −0.0076 | −0.0072 | 36.2719 | 33.0725 | 36.2428 | 15.44 % | 30.66 % | 15.86 % | |
0.00 | 0.00 | −0.0050 | −0.0057 | −0.0063 | 36.2726 | 36.4040 | 36.4653 | 15.77 % | 15.11 % | 14.85 % | |
0.05 | 0.00 | −0.0073 | −0.0034 | −0.0049 | 36.2420 | 38.1107 | 36.3738 | 15.75 % | 7.33 % | 15.23 % | |
0.10 | 0.00 | −0.0077 | −0.0011 | −0.0049 | 36.2214 | 39.1845 | 36.3761 | 15.91 % | 2.92 % | 14.88 % | |
0.15 | 0.00 | −0.0044 | −0.0008 | −0.0070 | 36.4279 | 39.6107 | 36.2580 | 14.86 % | 1.35 % | 15.47 % | |
0.20 | 0.00 | −0.0044 | −0.0016 | −0.0060 | 36.3945 | 39.8325 | 36.3640 | 15.06 % | 0.55 % | 15.29 % | |
100 | −0.20 | 0.00 | −0.0206 | 0.0305 | −0.0205 | 84.2873 | 15.4339 | 84.3159 | 22.80 % | 99.99 % | 22.82 % |
−0.15 | 0.00 | −0.0188 | −0.0007 | −0.0203 | 84.7484 | 24.5031 | 84.4050 | 21.95 % | 99.27 % | 22.22 % | |
−0.10 | 0.00 | −0.0202 | −0.0212 | −0.0197 | 84.4487 | 43.6230 | 84.5338 | 22.31 % | 85.84 % | 22.44 % | |
−0.05 | 0.00 | −0.0191 | −0.0276 | −0.0199 | 84.8712 | 66.7741 | 84.3454 | 21.99 % | 52.46 % | 22.57 % | |
0.00 | 0.00 | −0.0216 | −0.0207 | −0.0216 | 84.0536 | 84.2135 | 83.8033 | 22.86 % | 22.67 % | 23.36 % | |
0.05 | 0.00 | −0.0203 | −0.0115 | −0.0196 | 84.6003 | 93.1786 | 84.7271 | 22.28 % | 8.66 % | 22.24 % | |
0.10 | 0.00 | −0.0194 | −0.0050 | −0.0202 | 84.6521 | 97.3946 | 84.1845 | 21.94 % | 3.08 % | 22.76 % | |
0.15 | 0.00 | −0.0194 | −0.0023 | −0.0202 | 84.8085 | 98.9283 | 84.6060 | 22.00 % | 1.20 % | 22.06 % | |
0.20 | 0.00 | −0.0199 | −0.0024 | −0.0215 | 84.5757 | 99.4983 | 84.1044 | 22.02 % | 0.56 % | 22.94 % |