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Fig. 8 | BMC Medical Research Methodology

Fig. 8

From: Combined models for pre- and post-treatment longitudinal biomarker data: an application to CD4 counts in HIV-patients

Fig. 8

Predictions for hypothetical patients made from fitted model. Plots of the 90 % range of CD4 counts predicted by Model4 for a population of patients initiating highly active antiretroviral therapy (HAART) either within 6 months (ac) or more than 1 year (df) from seroconversion, with ‘true’ CD4 counts at treatment initiation of: a, d 200, b, e 350 and c, f 500 cells/ μL. The predicted ranges include measurement error (alongside the stochastic process component and variance in the subject-specific long-term maximum), explaining the variance present at time zero. The ranges shown have been back-transformed from the model predictions generated on the square-root scale

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