Table 3 Aggregated dose-response data of five clinical trials investigating effectiveness of different dosages of aripiprazole in schizoaffective patients. The continuous outcome is measured on the Positive and Negative Syndrome Scale and summarized by mean values (mean(Y)) and standard deviations (sd(Y))
ID | Author, Year | dose | mean(Y) | sd(Y) | n | d | Var(d) |
|---|---|---|---|---|---|---|---|
1 | Cutler, 2006 [28] | 0 | 5.300 | 18.310 | 85 | 0.000 | 0.000 |
| Â | Â | 2 | 8.230 | 18.320 | 92 | 2.930 | 7.593 |
| Â | Â | 5 | 10.600 | 18.310 | 89 | 5.300 | 7.715 |
| Â | Â | 10 | 11.300 | 18.320 | 94 | 6.000 | 7.515 |
2 | McEvoy, 2007 [29] | 0 | 2.330 | 26.100 | 107 | 0.000 | 0.000 |
| Â | Â | 10 | 15.040 | 27.600 | 103 | 12.710 | 13.344 |
| Â | Â | 15 | 11.730 | 26.200 | 103 | 9.400 | 13.344 |
| Â | Â | 20 | 14.440 | 25.900 | 97 | 12.110 | 13.764 |
3 | Kane, 2002 [30] | 0 | 2.900 | 24.280 | 102 | 0.000 | 0.000 |
| Â | Â | 15 | 15.500 | 26.490 | 99 | 12.600 | 12.038 |
| Â | Â | 30 | 11.400 | 22.900 | 100 | 8.500 | 11.977 |
4 | Potkin, 2003 [31] | 0 | 5.000 | 21.140 | 103 | 0.000 | 0.000 |
| Â | Â | 20 | 14.500 | 20.160 | 98 | 9.500 | 8.563 |
| Â | Â | 30 | 13.900 | 20.880 | 96 | 8.900 | 8.654 |
5 | Study 94202 [32] | 0 | 1.400 | 25.730 | 57 | 0.000 | 0.000 |
| Â | Â | 2 | 11.000 | 25.000 | 51 | 9.600 | 25.447 |
| Â | Â | 10 | 11.500 | 25.200 | 51 | 10.100 | 25.447 |
| Â | Â | 30 | 15.800 | 28.510 | 54 | 14.400 | 24.701 |