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Table 5 Probability of early termination at the first stage for the designs with π a =π u +0.2 and 80 % power

From: Minimax and admissible adaptive two-stage designs in phase II clinical trials

π u

Simon

Minimax-EF

New adaptive design

0.2

0.716

0.402

0.674

0.3

0.666

0.582

0.417

0.4

0.913

0.921

0.527

0.5

0.661

0.589

0.589

0.6

0.647

0.554

0.597

0.7

0.946

0.949

0.579