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How do researchers determine the difference to be detected in superiority trials? Results of a survey from a panel of researchers

  • Angèle Gayet-Ageron1Email author,
  • Anne-Sophie Jannot2,
  • Thomas Agoritsas3, 1,
  • Sandrine Rudaz1,
  • Christophe Combescure1 and
  • Thomas Perneger1
BMC Medical Research MethodologyBMC series – open, inclusive and trusted201616:89

Received: 4 March 2016

Accepted: 23 July 2016

Published: 29 July 2016

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Open Peer Review reports

Pre-publication versions of this article are available by contacting

Original Submission
4 Mar 2016 Submitted Original manuscript
Author responded Author comments
Reviewed Reviewer Report
Resubmission - Version 2
Submitted Manuscript version 2
Author responded Author comments
Reviewed Reviewer Report
Resubmission - Version 3
Submitted Manuscript version 3
Author responded Author comments
Resubmission - Version 4
Submitted Manuscript version 4
23 Jul 2016 Editorially accepted
29 Jul 2016 Article published 10.1186/s12874-016-0195-2

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article are available by contacting

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Authors’ Affiliations

Division of clinical-epidemiology, Department of health and community medicine, University of Geneva & University Hospitals of Geneva, Geneva, Switzerland
Department of Medical Informatics and Public Health, Hôpital Européen Georges Pompidou, Assistance Publique Hôpitaux de Paris, Paris, France
Department of Internal Medicine, Rehabilitation and Geriatrics, Geneva University Hospitals and Geneva Faculty of Medicine, Geneva 14, Switzerland