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Fig. 5 | BMC Medical Research Methodology

Fig. 5

From: Modelling multiple thresholds in meta-analysis of diagnostic test accuracy studies

Fig. 5

B type natriuretic peptide data. a Estimated distribution functions for the non-diseased (open circles, dashed line) and the diseased individuals (filled circles, solid line). The grey lines mark the confidence regions and different studies are marked in different colours. The optimal threshold, derived from a maximization of the Youden index, is depicted as a solid vertical line. b Estimated densities and their point of intersection. Non-diseased (dashed line), diseased individuals (solid line). c Study-specific ROC curves. d Estimated SROC curve with the optimal thresholds for different weightings of sensitivity and specificity marked as crosses in black, red and green. Different studies are marked in different colours

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