Table 1 Simulation results for the design in Fig. 1: the estimated means, based on 500 replicates, are reported for coefficients in model (4)

β ₁₂

β ₂₂

β ₂₃

β ₃₂

(first-stage interventions A ₁)

(second-stage interventions for responders A _2R )

(second-stage interventions for non-responders A _2NR )

(time of intervention T ₂)

0.4

0.5

0.5

2

Joint Model

Estimate

0.407

0.503

0.502

1.790

MSE

0.011

0.029

0.016

0.147

CI%

97.8 %

95.0 %

96.8 %

94.2 %

Length of CI

0.478

0.674

0.538

1.447

TVMEM

Estimate

0.275

0.503

0.501

4.073

MSE

0.026

0.030

0.017

4.400

CI%

88.0 %

95.6 %

97.0 %

0.0 %

Length of CI

0.484

0.695

0.549

1.436