Table 7 Simulation results for the design in Fig. 2: the estimated means, based on 500 replicates, are reported for coefficients in model (4) with interactions
From: Time-varying SMART design and data analysis methods for evaluating adaptive intervention effects
Parameter estimation | |||||
β 12 | β 23 | β 32 | β 42 | ||
(first-stage intervention A 1) | (second-stage interventions for responder A 2NR ) | (time of intervention T 2) | (interaction termA 1 A 2NR )) | ||
True value | 0.4 | 0.4 | 2.0 | −0.4 | |
Joint model | Estimate | 0.408 | 0.422 | 1.784 | −0.400 |
MSE | 0.012 | 0.020 | 0.157 | 0.019 | |
CI% | 98.2 % | 97.2 % | 95.6 % | 97.2 % | |
Length of CI | 0.513 | 0.594 | 1.542 | 0.593 | |
TVMEM | Estimate | 0.298 | 0.419 | 4.308 | −0.399 |
MSE | 0.021 | 0.021 | 5.439 | 0.020 | |
CI% | 94.8 % | 97.4 % | 0.0 % | 97.4 % | |
Length of CI | 0.520 | 0.608 | 1.532 | 0.607 | |