| Model 1 | Model 2 | Model 3 | Model 4 |
---|---|---|---|---|
Outcome type | Continuous | Continuous | Continuous | Continuous |
Outcome synthesised | Change from baseline | Change from baseline | Change from baseline | Final score |
Approach | ANCOVA (baseline adjustment) | ANCOVA (baseline adjustment) | No baseline adjustment | No baseline adjustment |
Pain interactions (case-study specific) | Yes | Yes | Yes | Yes |
Further adjustments | None | Patients characteristics as treatment-effect modifiers | None | None |