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Table 3 Average and range of c statistic and calibration slopes in the prostate cancer case-study

From: Improving prediction models with new markers: a comparison of updating strategies

Measure

Original Model

Model Revision

Model Revision with Shrinkage

Recalibration with extension

CLR

CLR simple

Imputation

c-statistic

0.69 [0.68–0.69]

0.73 [0.69–0.75]

0.74 [0.73–0.75]

0.74 [0.73–0.75]

0.74 [0.73–0.75]

0.74 [0.73–0.75]

0.73 [0.73–0.74]

Calibration Slope

0.77 [0.71–0.82]

0.76 [0.42–1.08]

0.75 [0.41–1.06]

0.96 [0.55–1.72]

0.61 [0.54–0.72]

0.74 [0.59–0.91]

0.78 [0.66–0.93]

  1. A previously developed prediction model (RC3) was extended with a marker (PHI) using data from one cohort and validated in four cohorts not used at model development