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Table 2 Chart-based studies of sepsis and severe sepsis incidence in the general population

From: Differences in reported sepsis incidence according to study design: a literature review

  Padkin, 2003 [54] Finfer, 2004 [48] Brun-Buisson, 2004 [45] Harrison, 2006 [53] Esteban, 2007 [47] Karlsson, 2007 [50] Blanco, 2008 [44] Vesteinsdottir, 2011 [52] Davis, 2011 [46] Nygard, 2014 [51] Henriksen, 2015 [49]
Country/region England, Wales and Northern Ireland Australia and New Zealand France England, Wales and Northern Ireland Madrid, Spain Finland Castilla y Leòn Region, Spain Iceland Northern territory, Australia Norway Denmark
Setting 91 ICUs 23 ICUs 206 ICUs 172 ICUs 3 hospitals 24 ICUs/11 hospitals 11 ICUs 3 ICUs 1 hospital 3 ICUs 1 ED
Study population 56,673 5,878 3,738 343,860 15,852 4,500 2,619 1,524 15,963 NA 8,358
Number of cases (sepsis/severe sepsis) NA/15,362 NA/691 NA/621 NA/92,672 702/199 NA/472 NA/246 NA/115 1,191/272 NA/220 621/1,071
Study duration 1995–2000 3 months 2 weeks 10 year 4 months 4 months /4 days 6 months 1 year 1 year 1 year 1 year
Exclusion criteria <16 years, readmissions, sepsis not present within 24 h from admission <15 years   <16 years, readmissions, sepsis not present within 24 h from admission < 18 years < 18 years, readmissions <18 years < 18 years, readmissions, sepsis not present on admission < 15 years < 15 years, severe sepsis not present within 24 h from admission, transferred with diagnosis of severe sepsis < 15 years, readmissions, immediately preceding hospitalisation
Sepsis inclusion criteria PROWESS Bone criteria Bone criteria PROWESS Bone criteria Bone criteria Bone criteria Bone criteria PROWESS Bone criteria Bone criteria
Organ failure inclusion criteria Modified PROWESS Modified PROWESS SOFA score ≥3 Modified PROWESS MODS score >2 SOFA score ≥3 Modified PROWESS Modified Bone criteria PROWESS Modified Levy et al. Protocol specified criteria
Calendar yeari 1997ii 1999 2001 1996; 2003 2003 2005 2002 2009 2008 2008 2011
Sepsis incidence 100.000 person yrs−1 367 1,180 265
Severe sepsis incidence 100.000 person yrs−1 51 77 95 46; 66 104 38 25 48 130 50 457
  1. Characteristics of chart based studies of sepsis and severe sepsis incidence extrapolated to the general population. i) If study is conducted in two consecutive calendar years the last year is reported. ii) If full data were not available for 1997, the closest full year’s data were used. Abbreviations: −, not calculated; ED emergency department, hrs hours, ICU intensive care unit, MODS multiple organ dysfunction syndrome, NA not available, PROWESS Protein C Worldwide Evaluation in Severe Sepsis, SOFA, sequential organ failure assessment, yrs years old