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Table 4 HU holding/de-escalation and stopping criteria

From: Rationale and design of mDOT-HuA study: a randomized trial to assess the effect of mobile-directly observed therapy on adherence to hydroxyurea in adults with sickle cell anemia in Tanzania

HU holding and de-escalation criteria HU stopping criteria
Absolute neutrophil count <1500/uL Positive urine pregnancy test
Platelet count <95,000/uL Any cytopenia that does not resolve after holding HU for 2 weeks
Hb <9 g/dL with absolute reticulocyte count <95,000/uL Request of the subject or proxy (withdrawal of consent by the subject)
  Investigator’s discretion
  Subject is lost to follow-up