BMC Medical Research Methodology

Table 4 Comparison of longitudinal effect on survival (N = 1000)

From: A comparison of time dependent Cox regression, pooled logistic regression and cross sectional pooling with simulations and an application to the Framingham Heart Study

Scenarios		CSP_UNADJUSTED					CSP_ADJUSTED & TDCM
Event rate	γ	Estimate	SE	CP	Bias	MSE	Estimate	SE	CP	Bias	MSE
90 %	0.000	0.003	0.054	0.957	0.003	0.006	0.003	0.055	0.954	0.003	0.006
	0.500	0.498	0.055	0.954	−0.002	0.006	0.498	0.056	0.952	−0.002	0.006
	1.000	1.083	0.058	0.720	0.082	0.014	1.002	0.059	0.958	0.002	0.007
50 %	0.000	−0.001	0.075	0.953	−0.001	0.011	−0.002	0.076	0.944	−0.002	0.012
	0.500	0.499	0.070	0.947	−0.001	0.010	0.499	0.071	0.944	−0.001	0.010
	1.000	1.001	0.073	0.946	0.001	0.011	1.002	0.074	0.948	0.002	0.011
10 %	0.000	0.007	0.168	0.944	0.007	0.058	0.007	0.171	0.938	0.007	0.060
	0.500	0.501	0.158	0.947	0.001	0.051	0.501	0.161	0.946	0.001	0.053
	1.000	1.067	0.145	0.906	0.067	0.048	1.003	0.147	0.937	0.003	0.045
		PLR_UNADJUSTED					PLR_ADJUSTED
Event rate	γ	Estimate	SE	CP	Bias	MSE	Estimate	SE	CP	Bias	MSE
90 %	0.000	0.003	0.066	0.957	0.003	0.008	0.003	0.067	0.957	0.003	0.009
	0.500	0.599	0.069	0.709	0.099	0.019	0.601	0.070	0.711	0.101	0.020
	1.000	1.342	0.080	0.005	0.342	0.130	1.255	0.082	0.111	0.255	0.078
50 %	0.000	−0.001	0.080	0.950	−0.001	0.013	−0.002	0.081	0.945	−0.002	0.013
	0.500	0.545	0.077	0.909	0.045	0.014	0.545	0.079	0.912	0.045	0.014
	1.000	1.109	0.084	0.746	0.109	0.026	1.109	0.086	0.744	0.109	0.027
10 %	0.000	0.007	0.170	0.945	0.007	0.059	0.007	0.173	0.937	0.007	0.061
	0.500	0.510	0.161	0.947	0.010	0.053	0.509	0.164	0.941	0.009	0.055
	1.000	1.091	0.150	0.888	0.091	0.055	1.027	0.152	0.926	0.027	0.049

Abbreviations: SE Standard Error, CP 95 % Coverage Probability, MSE Mean Square Error, CSP_UN Unadjusted Cross Sectional Pooling, CSP_AD Adjusted Cross Sectional Pooling; PLR_UN Unadjusted Pooled Logistic Regression, PLR_AD Adjusted Pooled Logistic Regression, TDCM Time Dependent Cox Regression Modeling

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ISSN: 1471-2288

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