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Table 11 TESAOD application, overweight subjects (N = 463 normal-weight, N = 306 overweight)

From: Least absolute shrinkage and selection operator type methods for the identification of serum biomarkers of overweight and obesity: simulation and application

  Lasso Adaptive LASSO Elastic Net Iterated LASSO Bootstrap-Enhanced LASSO-75 Weighted Fusion Logistic Regression, Coefficient (p-value)
Adiponectin −0.2511 −0.3500 −0.2498 −0.3297 −0.3226 −0.2440 −0.5188 (<0.001)
Alpha-1 Antitrypsin −0.0283 −0.0283 −0.0554 −0.1381 0 −0.0210 −0.1552 (0.038)
Alpha-Fetoprotein 0 0 0 0 0 0 0.1012 (0.178)
Alpha-2 Macroglobulin −0.0005 0 −0.0214 0 0 −0.0014 −0.3183 (<0.001)
Apolipoprotein A-1 0 0 0 0 0 0 −0.0502 (0.497)
Apolipoprotein C-III 0 0 0 0 0 0 0.2049 (0.006)
Apolipoprotein H 0.0571 0.0838 0.0762 0.1479 0.1309 0.0512 0.3348 (<0.001)
Beta-2 Microglobulin 0 0 0 0 0 0 0.1495 (0.044)
Brain Derived Neurotrophic Factor 0 0 0 0 0 0 0.0412 (0.576)
Calcitonina 0.0469 0.0765 0.0668 0.1681 0.0895 0.0352 0.3435 (0.020)
Cancer Antigen 19-9 0 0 0 0 0 0 −0.0007 (0.992)
Cancer Antigen 125 0 0 0 0 0 0 0.0724 (0.329)
Carcinoembryonic Antigen 0 0 0 0 0 0 0.0157 (0.831)
Soluble CD14 −0.1133 −0.1679 −0.1296 −0.2492 −0.1923 −0.0994 −0.1716 (0.023)
CD40 0 0 0 0 0 0 0.0302 (0.682)
CD40Ligand 0 0 0 0 0 0 −0.0096 (0.896)
Club Cell Secretory Protein 0 0 0 0 0 0 0.0107 (0.885)
Complement 3 0.0847 0.1238 0.1183 0.2080 0.1483 0.0767 0.3855 (<0.001)
C-Reactive Protein 0.2105 0.3150 0.2188 0.3791 0.2902 0.1923 0.3537 (<0.001)
Creatine Kinase-MB 0 0 0.0062 0 0 0 0.2130 (0.005)
Endothelin-1b 0 0 0 0 0 0 −0.0262 (0.874)
Eotaxin −0.0451 −0.0904 −0.0693 −0.1443 −0.1277 −0.0335 −0.0946 (0.206)
Epidermal Growth Factor −0.0140 −0.0591 −0.0396 −0.1180 −0.0689 −0.0041 −0.1000 (0.174)
Epithelial-Derived Neutrophil-Activating Protein-78 0 0 0 0 0 0 −0.0065 (0.930)
Erythropoietina 0 0 0 0 0 0 0.0914 (0.535)
Extracellular Newly Identified RAGE-Binding Protein 0 0 0 0 0 0 0.0347 (0.637)
Fatty Acid Binding Protein 0 0 0 0 0 0 0.2592 (0.001)
Ferritin 0.1131 0.0969 0.1120 0.1431 0.1055 0.1115 0.4215 (<0.001)
Fibrinogen 0 0 0 0 0 0 0.1263 (0.087)
Fibroblast Growth Factor-Basicb 0 0 0 0 0 0 0.1792 (0.251)
Granulocyte Colony-Stimulating Factor −0.0713 −0.1647 −0.0879 −0.2319 −0.1709 −0.0547 −0.1155 (0.117)
Granulocyte-Macrophage Colony-Stimulating Factorb 0.0255 0 0.0445 0.1224 0 0.0153 0.4067 (0.036)
Growth Hormone −0.1163 −0.1238 −0.1259 −0.1737 −0.1566 −0.1144 −0.4159 (<0.001)
Haptoglobin 0 0 0 0 0 0 0.1710 (0.023)
Immunoglobulin A 0 0 0 0 0 0 0.1227 (0.094)
Immunoglobulin E 0 0 0 0 0 0 0.1331 (0.074)
Immunoglobulin M −0.0410 −0.0288 −0.0569 −0.1228 −0.0949 −0.0320 −0.1509 (0.041)
Intercellular Adhesion Molecule-1 0 0 0 0 0 0 0.0608 (0.411)
Interferon-Gammaa 0 0 0 0 0 0 −0.0739 (0.616)
Interleukin-1alphab 0 0 −0.0097 0 0 0 −0.2350 (0.134)
Interleukin-1betaa 0 0 0 0 0 0 0.1519 (0.303)
Interleukin-1 Receptor Antagonist 0 0 0 0 0 0 0.0141 (0.849)
Interleukin-3b 0 0 0.0027 0 0.0167 0 0.0991 (0.504)
Interleukin-4b 0 0 −0.0022 0 0 0 −0.2057 (0.172)
Interleukin-5a 0 0 0 0 0 0 −0.0003 (0.998)
Interleukin-6a 0 0 0 0 0 0 0.1995 (0.176)
Interleukin-7b 0 0 0.0014 0 0 0 0.1563 (0.292)
Interleukin-8 0 0.0155 0.0089 0 0 0 0.0810 (0.269)
Interleukin-10b 0 0 0 0 0 0 0.1657 (0.316)
Interleukin-12p40b −0.0089 0 −0.0351 −0.1216 0 0 −0.2502 (0.146)
Interleukin-13 0 0 0 0 0 0 −0.0110 (0.881)
Interleukin-15a 0 0 0 0 0 0 −0.1304 (0.376)
Interleukin-16 0 −0.0597 0 0 0 0 0.0584 (0.433)
Interleukin-18 0.0073 0.0047 0.0348 0.1515 0 0 0.2131 (0.005)
Leptin 0.2057 0.3263 0.2102 0.3690 0.3177 0.1829 0.2062 (0.008)
Lipoprotein (a) 0 0 0 0 0 0 −0.1247 (0.094)
Macrophage-Derived Chemokine 0 0 0 0 0 0 0.0477 (0.517)
Macrophage Inflammatory Protein-1alpha 0 0 0 0 0 0 0.1057 (0.156)
Macrophage Inflammatory Protein-1beta 0.0002 0 0.0307 0 0 0 0.1679 (0.026)
Matrix Metalloproteinase-2a 0 0 0 0 0 0 0.0212 (0.886)
Matrix Metalloproteinase-3 0 0 0 0 0 0 0.1937 (0.010)
Matrix Metalloproteinase-9a 0 0 0 0 0 0 0.1040 (0.480)
Monocyte Chemotactic Protein-1 0 0 0 0 0 0 0.1189 (0.110)
Myeloperoxidase −0.0222 0 −0.0378 −0.1046 0 −0.0113 −0.0582 (0.430)
Myoglobin 0.2323 0.3468 0.2300 0.3341 0.2856 0.2162 0.4412 (<0.001)
Plasminogen Activator Inhibitor 1 0 0 0 0 0 0 0.1848 (0.014)
Pregnancy-Associated Plasma Protein a 0 0 0 0 0 0 −0.0047 (0.949)
Prostatic Acid Phosphatasea 0 0 0 0 0 0 0.2134 (0.148)
T-Cell Specific Protein RANTES 0 0 0 0 0 0 0.0804 (0.278)
Serum Amyloid P 0.1352 0 0.1196 0.0851 0.1133 0.1346 0.5442 (<0.001)
Serum Glutamic Oxaloacetic Transminase 0 0 0.0206 0 0 0 0.0672 (0.364)
Sex Hormone Binding Globulin −0.2130 −0.2033 −0.1979 −0.2220 −0.2046 −0.2009 −0.5329 (<0.001)
Stem Cell Factor 0 0 0 0 0 0 0.0395 (0.591)
Surfactant Protein D −0.1053 −0.1518 −0.1250 −0.2361 −0.2089 −0.0924 −0.1774 (0.020)
Thrombopoietin 0 0 0 0 0 0 0.0218 (0.767)
Thyroid Stimulating Hormone 0 0 −0.0080 0 0 0 −0.0191 (0.795)
Thyroxine Binding Globulin 0 0 0 0 0 0 −0.1083 (0.150)
Tissue Factorb 0 0 0 0 0 0 −0.0137 (0.945)
Tissue Inhibitor of Metalloproteinase 1 0 0 0 0 0 0 0.1395 (0.059)
Tumor Necrosis Factor-alpha 0 0 0 0 0 0 0.0616 (0.407)
Tumor Necrosis Factor-betab 0 0 0 0 0 0 −0.0666 (0.682)
Tumor Necrosis Factor RII 0 0 0 0 0 0 0.1413 (0.056)
Vascular Cell Adhesion Molecule-1 0 0 0 0 0 0 0.0698 (0.344)
Vascular Endothelial Growth Factor 0 0 0 0 0 0 0.1098 (0.138)
von Willebrand Factor 0 0 0 0 0 0 0.0579 (0.430)
YKL-40 0 0 0.0108 0 0 0 0.1184 (0.108)
  1. aCategorized at median; bCategorized at detection limit
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BMC Medical Research Methodology

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