Table 11 TESAOD application, overweight subjects (N = 463 normal-weight, N = 306 overweight)
| Â | Lasso | Adaptive LASSO | Elastic Net | Iterated LASSO | Bootstrap-Enhanced LASSO-75 | Weighted Fusion | Logistic Regression, Coefficient (p-value) |
|---|---|---|---|---|---|---|---|
Adiponectin | −0.2511 | −0.3500 | −0.2498 | −0.3297 | −0.3226 | −0.2440 | −0.5188 (<0.001) |
Alpha-1 Antitrypsin | −0.0283 | −0.0283 | −0.0554 | −0.1381 | 0 | −0.0210 | −0.1552 (0.038) |
Alpha-Fetoprotein | 0 | 0 | 0 | 0 | 0 | 0 | 0.1012 (0.178) |
Alpha-2 Macroglobulin | −0.0005 | 0 | −0.0214 | 0 | 0 | −0.0014 | −0.3183 (<0.001) |
Apolipoprotein A-1 | 0 | 0 | 0 | 0 | 0 | 0 | −0.0502 (0.497) |
Apolipoprotein C-III | 0 | 0 | 0 | 0 | 0 | 0 | 0.2049 (0.006) |
Apolipoprotein H | 0.0571 | 0.0838 | 0.0762 | 0.1479 | 0.1309 | 0.0512 | 0.3348 (<0.001) |
Beta-2 Microglobulin | 0 | 0 | 0 | 0 | 0 | 0 | 0.1495 (0.044) |
Brain Derived Neurotrophic Factor | 0 | 0 | 0 | 0 | 0 | 0 | 0.0412 (0.576) |
Calcitonina | 0.0469 | 0.0765 | 0.0668 | 0.1681 | 0.0895 | 0.0352 | 0.3435 (0.020) |
Cancer Antigen 19-9 | 0 | 0 | 0 | 0 | 0 | 0 | −0.0007 (0.992) |
Cancer Antigen 125 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0724 (0.329) |
Carcinoembryonic Antigen | 0 | 0 | 0 | 0 | 0 | 0 | 0.0157 (0.831) |
Soluble CD14 | −0.1133 | −0.1679 | −0.1296 | −0.2492 | −0.1923 | −0.0994 | −0.1716 (0.023) |
CD40 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0302 (0.682) |
CD40Ligand | 0 | 0 | 0 | 0 | 0 | 0 | −0.0096 (0.896) |
Club Cell Secretory Protein | 0 | 0 | 0 | 0 | 0 | 0 | 0.0107 (0.885) |
Complement 3 | 0.0847 | 0.1238 | 0.1183 | 0.2080 | 0.1483 | 0.0767 | 0.3855 (<0.001) |
C-Reactive Protein | 0.2105 | 0.3150 | 0.2188 | 0.3791 | 0.2902 | 0.1923 | 0.3537 (<0.001) |
Creatine Kinase-MB | 0 | 0 | 0.0062 | 0 | 0 | 0 | 0.2130 (0.005) |
Endothelin-1b | 0 | 0 | 0 | 0 | 0 | 0 | −0.0262 (0.874) |
Eotaxin | −0.0451 | −0.0904 | −0.0693 | −0.1443 | −0.1277 | −0.0335 | −0.0946 (0.206) |
Epidermal Growth Factor | −0.0140 | −0.0591 | −0.0396 | −0.1180 | −0.0689 | −0.0041 | −0.1000 (0.174) |
Epithelial-Derived Neutrophil-Activating Protein-78 | 0 | 0 | 0 | 0 | 0 | 0 | −0.0065 (0.930) |
Erythropoietina | 0 | 0 | 0 | 0 | 0 | 0 | 0.0914 (0.535) |
Extracellular Newly Identified RAGE-Binding Protein | 0 | 0 | 0 | 0 | 0 | 0 | 0.0347 (0.637) |
Fatty Acid Binding Protein | 0 | 0 | 0 | 0 | 0 | 0 | 0.2592 (0.001) |
Ferritin | 0.1131 | 0.0969 | 0.1120 | 0.1431 | 0.1055 | 0.1115 | 0.4215 (<0.001) |
Fibrinogen | 0 | 0 | 0 | 0 | 0 | 0 | 0.1263 (0.087) |
Fibroblast Growth Factor-Basicb | 0 | 0 | 0 | 0 | 0 | 0 | 0.1792 (0.251) |
Granulocyte Colony-Stimulating Factor | −0.0713 | −0.1647 | −0.0879 | −0.2319 | −0.1709 | −0.0547 | −0.1155 (0.117) |
Granulocyte-Macrophage Colony-Stimulating Factorb | 0.0255 | 0 | 0.0445 | 0.1224 | 0 | 0.0153 | 0.4067 (0.036) |
Growth Hormone | −0.1163 | −0.1238 | −0.1259 | −0.1737 | −0.1566 | −0.1144 | −0.4159 (<0.001) |
Haptoglobin | 0 | 0 | 0 | 0 | 0 | 0 | 0.1710 (0.023) |
Immunoglobulin A | 0 | 0 | 0 | 0 | 0 | 0 | 0.1227 (0.094) |
Immunoglobulin E | 0 | 0 | 0 | 0 | 0 | 0 | 0.1331 (0.074) |
Immunoglobulin M | −0.0410 | −0.0288 | −0.0569 | −0.1228 | −0.0949 | −0.0320 | −0.1509 (0.041) |
Intercellular Adhesion Molecule-1 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0608 (0.411) |
Interferon-Gammaa | 0 | 0 | 0 | 0 | 0 | 0 | −0.0739 (0.616) |
Interleukin-1alphab | 0 | 0 | −0.0097 | 0 | 0 | 0 | −0.2350 (0.134) |
Interleukin-1betaa | 0 | 0 | 0 | 0 | 0 | 0 | 0.1519 (0.303) |
Interleukin-1 Receptor Antagonist | 0 | 0 | 0 | 0 | 0 | 0 | 0.0141 (0.849) |
Interleukin-3b | 0 | 0 | 0.0027 | 0 | 0.0167 | 0 | 0.0991 (0.504) |
Interleukin-4b | 0 | 0 | −0.0022 | 0 | 0 | 0 | −0.2057 (0.172) |
Interleukin-5a | 0 | 0 | 0 | 0 | 0 | 0 | −0.0003 (0.998) |
Interleukin-6a | 0 | 0 | 0 | 0 | 0 | 0 | 0.1995 (0.176) |
Interleukin-7b | 0 | 0 | 0.0014 | 0 | 0 | 0 | 0.1563 (0.292) |
Interleukin-8 | 0 | 0.0155 | 0.0089 | 0 | 0 | 0 | 0.0810 (0.269) |
Interleukin-10b | 0 | 0 | 0 | 0 | 0 | 0 | 0.1657 (0.316) |
Interleukin-12p40b | −0.0089 | 0 | −0.0351 | −0.1216 | 0 | 0 | −0.2502 (0.146) |
Interleukin-13 | 0 | 0 | 0 | 0 | 0 | 0 | −0.0110 (0.881) |
Interleukin-15a | 0 | 0 | 0 | 0 | 0 | 0 | −0.1304 (0.376) |
Interleukin-16 | 0 | −0.0597 | 0 | 0 | 0 | 0 | 0.0584 (0.433) |
Interleukin-18 | 0.0073 | 0.0047 | 0.0348 | 0.1515 | 0 | 0 | 0.2131 (0.005) |
Leptin | 0.2057 | 0.3263 | 0.2102 | 0.3690 | 0.3177 | 0.1829 | 0.2062 (0.008) |
Lipoprotein (a) | 0 | 0 | 0 | 0 | 0 | 0 | −0.1247 (0.094) |
Macrophage-Derived Chemokine | 0 | 0 | 0 | 0 | 0 | 0 | 0.0477 (0.517) |
Macrophage Inflammatory Protein-1alpha | 0 | 0 | 0 | 0 | 0 | 0 | 0.1057 (0.156) |
Macrophage Inflammatory Protein-1beta | 0.0002 | 0 | 0.0307 | 0 | 0 | 0 | 0.1679 (0.026) |
Matrix Metalloproteinase-2a | 0 | 0 | 0 | 0 | 0 | 0 | 0.0212 (0.886) |
Matrix Metalloproteinase-3 | 0 | 0 | 0 | 0 | 0 | 0 | 0.1937 (0.010) |
Matrix Metalloproteinase-9a | 0 | 0 | 0 | 0 | 0 | 0 | 0.1040 (0.480) |
Monocyte Chemotactic Protein-1 | 0 | 0 | 0 | 0 | 0 | 0 | 0.1189 (0.110) |
Myeloperoxidase | −0.0222 | 0 | −0.0378 | −0.1046 | 0 | −0.0113 | −0.0582 (0.430) |
Myoglobin | 0.2323 | 0.3468 | 0.2300 | 0.3341 | 0.2856 | 0.2162 | 0.4412 (<0.001) |
Plasminogen Activator Inhibitor 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0.1848 (0.014) |
Pregnancy-Associated Plasma Protein a | 0 | 0 | 0 | 0 | 0 | 0 | −0.0047 (0.949) |
Prostatic Acid Phosphatasea | 0 | 0 | 0 | 0 | 0 | 0 | 0.2134 (0.148) |
T-Cell Specific Protein RANTES | 0 | 0 | 0 | 0 | 0 | 0 | 0.0804 (0.278) |
Serum Amyloid P | 0.1352 | 0 | 0.1196 | 0.0851 | 0.1133 | 0.1346 | 0.5442 (<0.001) |
Serum Glutamic Oxaloacetic Transminase | 0 | 0 | 0.0206 | 0 | 0 | 0 | 0.0672 (0.364) |
Sex Hormone Binding Globulin | −0.2130 | −0.2033 | −0.1979 | −0.2220 | −0.2046 | −0.2009 | −0.5329 (<0.001) |
Stem Cell Factor | 0 | 0 | 0 | 0 | 0 | 0 | 0.0395 (0.591) |
Surfactant Protein D | −0.1053 | −0.1518 | −0.1250 | −0.2361 | −0.2089 | −0.0924 | −0.1774 (0.020) |
Thrombopoietin | 0 | 0 | 0 | 0 | 0 | 0 | 0.0218 (0.767) |
Thyroid Stimulating Hormone | 0 | 0 | −0.0080 | 0 | 0 | 0 | −0.0191 (0.795) |
Thyroxine Binding Globulin | 0 | 0 | 0 | 0 | 0 | 0 | −0.1083 (0.150) |
Tissue Factorb | 0 | 0 | 0 | 0 | 0 | 0 | −0.0137 (0.945) |
Tissue Inhibitor of Metalloproteinase 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0.1395 (0.059) |
Tumor Necrosis Factor-alpha | 0 | 0 | 0 | 0 | 0 | 0 | 0.0616 (0.407) |
Tumor Necrosis Factor-betab | 0 | 0 | 0 | 0 | 0 | 0 | −0.0666 (0.682) |
Tumor Necrosis Factor RII | 0 | 0 | 0 | 0 | 0 | 0 | 0.1413 (0.056) |
Vascular Cell Adhesion Molecule-1 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0698 (0.344) |
Vascular Endothelial Growth Factor | 0 | 0 | 0 | 0 | 0 | 0 | 0.1098 (0.138) |
von Willebrand Factor | 0 | 0 | 0 | 0 | 0 | 0 | 0.0579 (0.430) |
YKL-40 | 0 | 0 | 0.0108 | 0 | 0 | 0 | 0.1184 (0.108) |