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Table 12 TESAOD application, obese subjects (N = 463 normal-weight, N = 66 obese)

From: Least absolute shrinkage and selection operator type methods for the identification of serum biomarkers of overweight and obesity: simulation and application

  Lasso Adaptive LASSO Elastic Net Iterated LASSO Bootstrap-Enhanced LASSO-75 Weighted Fusion Logistic Regression, Coefficient (p-value)
Adiponectin −0.0101 0 −0.0006 0 0 −0.0853 −0.3089 (0.018)
Alpha-1 Antitrypsin 0 0 0 0 0 −0.0320 −0.0748 (0.573)
Alpha-Fetoprotein −0.0256 0 0 0 0 −0.0730 0.0009 (0.994)
Alpha-2 Macroglobulin −0.0187 0 −0.0065 0 0 −0.1110 −0.3163 (0.022)
Apolipoprotein A-1 −0.2167 −0.3546 −0.1691 −0.3127 −0.2627 −0.1011 −0.1488 (0.260)
Apolipoprotein C-III 0 0 0 0 0 0 0.1865 (0.121)
Apolipoprotein H 0.0881 0.1642 0.0346 0 0.2160 0.1277 0.5315 (<0.001)
Beta-2 Microglobulin 0 0 0 0 0 0.0417 0.3586 (0.005)
Brain Derived Neurotrophic Factor 0 0 0 0 0 0 0.2784 (0.024)
Calcitonina 0 0 0 0 0 0.0624 0.2469 (0.349)
Cancer Antigen 19-9 −0.1216 −0.1226 −0.0633 0 −0.3059 −0.1439 −0.1357 (0.269)
Cancer Antigen 125 0 0 0 0 0 −0.0081 0.0942 (0.484)
Carcinoembryonic Antigen −0.0516 0 0 0 −0.1779 −0.1107 −0.1338 (0.301)
Soluble CD14 −0.1020 −0.1706 −0.0488 0 −0.2272 −0.0965 −0.0801 (0.544)
CD40 0 0 0 0 0 −0.0167 0.2122 (0.109)
CD40Ligand −0.0176 0 0 0 0 −0.0808 −0.0731 (0.580)
Club Cell Secretory Protein 0 0 0 0 0 −0.0705 −0.1442 (0.263)
Complement 3 0.0899 0 0.0761 0 0 0.1306 0.5991 (<0.001)
C-Reactive Protein 0.5213 0.7636 0.4765 0.6802 0.6052 0.2526 0.7864 (<0.001)
Creatine Kinase-MB 0.0818 0.1652 0.0423 0 0.1442 0.0957 0.2967 (0.045)
Endothelin-1b 0 0 0 0 0 0.0487 0.2000 (0.481)
Eotaxin −0.0965 −0.1557 −0.0581 0 −0.2893 −0.1414 −0.2317 (0.111)
Epidermal Growth Factor 0 0 0 0 0 0.0190 0.1794 (0.198)
Epithelial-Derived Neutrophil-Activating Protein-78 0 0 0 0 0 0.0353 0.2525 (0.024)
Erythropoietina 0 0 0 0 0 −0.0174 0.0736 (0.780)
Extracellular Newly Identified RAGE-Binding Protein 0 0 0 0 0 0.0092 0.0324 (0.803)
Fatty Acid Binding Protein 0 0 0 0 0 0 0.3317 (0.029)
Ferritin 0.0753 0 0.0469 0 0 0.0671 0.2900 (0.038)
Fibrinogen 0 0 0 0 0 0.0168 0.1290 (0.320)
Fibroblast Growth Factor-Basicb 0 0 0 0 0 0.0518 0.4799 (0.074)
Granulocyte Colony-Stimulating Factor 0 0 0 0 0 0.0705 0.3130 (0.027)
Granulocyte-Macrophage Colony-Stimulating Factorb 0 0 0 0 0 0.0086 0.2726 (0.430)
Growth Hormone 0 0 0 0 0 −0.0888 −0.2576 (0.049)
Haptoglobin 0 0 0 0 0 0.0107 0.2537 (0.027)
Immunoglobulin A 0 0 0 0 0 −0.0046 0.1143 (0.358)
Immunoglobulin E 0 0 0 0 0 0 −0.0469 (0.720)
Immunoglobulin M −0.1014 0 −0.0450 0 0 −0.1120 −0.1411 (0.278)
Intercellular Adhesion Molecule-1 0 0 0 0 0 0 0.1826 (0.167)
Interferon-Gammaa 0.0820 0.0300 0.0245 0 0.1199 0.1218 0.3461 (0.195)
Interleukin-1alphab 0 0 0 0 0 0.0154 0.1322 (0.624)
Interleukin-1betaa 0 0 0 0 0 0.0535 0.2558 (0.333)
Interleukin-1 Receptor Antagonist 0 −0.0844 0 0 0 −0.0275 0.1284 (0.353)
Interleukin-3b 0 0 0 0 0 −0.0185 0.1956 (0.458)
Interleukin-4b 0 0 0 0 0 0 −0.0315 (0.906)
Interleukin-5a 0 0 0 0 0 −0.0203 −0.0217 (0.934)
Interleukin-6a 0 0 0 0 0 −0.0069 0.4395 (0.098)
Interleukin-7b 0.1132 0 0.0761 0.012 0 0.1345 0.6057 (0.023)
Interleukin-8 −0.0407 0 0 0 0 −0.0765 −0.0588 (0.665)
Interleukin-10b 0 0 0 0 0 0.0124 0.4472 (0.110)
Interleukin-12p40b 0 0 0 0 0 0.0103 0.2217 (0.435)
Interleukin-13 0 0 0 0 0 −0.0653 −0.0841 (0.533)
Interleukin-15a 0 0 0 0 0 −0.0037 0.1434 (0.587)
Interleukin-16 0 0 0 0 0 0.0531 0.1822 (0.175)
Interleukin-18 0.1214 0.0653 0.0804 0.0774 0.2373 0.0870 0.3215 (0.015)
Leptin 0.9186 1.1286 0.8548 1.2502 1.1505 0.3792 1.3928 (<0.001)
Lipoprotein (a) 0 0 0 0 0 0 −0.0010 (0.994)
Macrophage-Derived Chemokine 0 0 0 0 0 0.0476 0.2533 (0.042)
Macrophage Inflammatory Protein-1alpha 0 0 0 0 0 0.0531 0.2623 (0.057)
Macrophage Inflammatory Protein-1beta 0 0 0 0 0 0.0241 0.2934 (0.022)
Matrix Metalloproteinase-2a 0.1090 0 0.0776 0.0443 0.1443 0.1242 0.6992 (0.011)
Matrix Metalloproteinase-3 0 0 0 0 0 −0.0308 −0.0218 (0.868)
Matrix Metalloproteinase-9a 0.0101 0.0832 0 0 0 0.0606 0.3084 (0.244)
Monocyte Chemotactic Protein-1 0.1628 0.1471 0.1269 0.1792 0.2546 0.1275 0.4521 (0.001)
Myeloperoxidase 0 −0.0542 0 0 0 −0.0927 −0.1054 (0.425)
Myoglobin 0.0391 0 0.0316 0 0 0.0829 0.3239 (0.011)
Plasminogen Activator Inhibitor 1 0 0 0 0 0 0.0454 0.4603 (0.001)
Pregnancy-Associated Plasma Protein a 0 0 0 0 0 −0.0995 −0.1306 (0.306)
Prostatic Acid Phosphatasea 0 0 0 0 0 −0.0477 −0.0652 (0.805)
T-Cell Specific Protein RANTES 0 0 0 0 0 0.0444 0.4370 (0.002)
Serum Amyloid P 0 0 0.0019 0 0 0.0836 0.6526 (<0.001)
Serum Glutamic Oxaloacetic Transminase 0.0340 0.0234 0 0 0 0.0851 0.0350 (0.791)
Sex Hormone Binding Globulin −0.4768 −0.6470 −0.4499 −0.7274 −0.4767 −0.2334 −0.5552 (<0.001)
Stem Cell Factor 0 0 0 0 0 0.0212 0.3146 (0.008)
Surfactant Protein D −0.3136 −0.4086 −0.2351 −0.3848 −0.4663 −0.2820 −0.4833 (0.002)
Thrombopoietin 0.0243 0 0.0147 0 0 0.0933 0.3849 (0.002)
Thyroid Stimulating Hormone −0.0264 −0.0034 0 0 0 −0.0515 −0.1010 (0.424)
Thyroxine Binding Globulin 0 0 0 0 0 0 0.0722 (0.570)
Tissue Factorb 0 0 0 0 0 0.0788 0.6627 (0.029)
Tissue Inhibitor of Metalloproteinase 1 0 0 0 0 0 −0.0023 0.2617 (0.031)
Tumor Necrosis Factor-alpha 0 0 0 0 0 0.0380 0.2958 (0.044)
Tumor Necrosis Factor-betab 0.0165 0 0 0 0 0.0848 0.2309 (0.406)
Tumor Necrosis Factor RII 0 0 0 0 0 0.0287 0.3291 (0.011)
Vascular Cell Adhesion Molecule-1 0 0.1194 0 0 0 0.0828 0.2680 (0.043)
Vascular Endothelial Growth Factor 0 0 0 0 0 0 0.3250 (0.015)
von Willebrand Factor 0.1980 0.0683 0.1737 0.2571 0.2694 0.1364 0.4185 (<0.001)
YKL-40 0.1095 0.0847 0.0733 0.0314 0.1979 0.1151 0.3671 (0.005)
  1. aCategorized at median; bCategorized at detection limit