Table 13 TESAOD application, overweight and obese subjects combined (N = 463 normal-weight, N = 372 overweight and obese)
| Â | Lasso | Adaptive LASSO | Elastic Net | Iterated LASSO | Bootstrap-Enhanced LASSO-75 | Weighted Fusion | Logistic Regression, Coefficient (p-value) |
|---|---|---|---|---|---|---|---|
Adiponectin | −0.2143 | −0.2770 | −0.2210 | −0.2827 | −0.2334 | −0.1985 | −0.4799 (<0.001) |
Alpha-1 Antitrypsin | −0.0311 | 0 | −0.0464 | 0 | 0 | −0.0199 | −0.1415 (0.045) |
Alpha-Fetoprotein | 0 | 0 | 0 | 0 | 0 | 0 | 0.0833 (0.238) |
Alpha-2 Macroglobulin | −0.0435 | 0 | −0.0580 | −0.0276 | −0.0705 | −0.0348 | −0.3158 (<0.001) |
Apolipoprotein A-1 | −0.0105 | −0.0257 | −0.0324 | 0 | 0 | 0 | −0.0684 (0.328) |
Apolipoprotein C-III | 0 | 0 | 0 | 0 | 0 | 0 | 0.2077 (0.003) |
Apolipoprotein H | 0.0759 | 0.1047 | 0.0965 | 0.1028 | 0.1201 | 0.0628 | 0.3683 (<0.001) |
Beta-2 Microglobulin | 0 | 0 | 0 | 0 | 0 | 0 | 0.1925 (0.007) |
Brain Derived Neurotrophic Factor | 0 | 0 | 0 | 0 | 0 | 0 | 0.0886 (0.206) |
Calcitonina | 0.0461 | 0.0647 | 0.0657 | 0.0782 | 0.1076 | 0.0236 | 0.3263 (0.020) |
Cancer Antigen 19-9 | 0 | 0 | 0 | 0 | 0 | 0 | −0.0265 (0.703) |
Cancer Antigen 125 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0769 (0.272) |
Carcinoembryonic Antigen | 0 | 0 | 0 | 0 | 0 | 0 | −0.0118 (0.866) |
Soluble CD14 | −0.1439 | −0.2052 | −0.1598 | −0.2411 | −0.1681 | −0.1143 | −0.1542 (0.030) |
CD40 | 0 | −0.0075 | −0.0085 | 0 | 0 | 0 | 0.0618 (0.376) |
CD40Ligand | 0 | 0 | 0 | 0 | 0 | 0 | −0.0206 (0.768) |
Club Cell Secretory Protein | 0 | 0 | −0.0009 | 0 | 0 | 0 | −0.0177 (0.799) |
Complement 3 | 0.1094 | 0.1174 | 0.1313 | 0.1307 | 0.1337 | 0.0923 | 0.4334 (<0.001) |
C-Reactive Protein | 0.2968 | 0.4064 | 0.3015 | 0.4235 | 0.3485 | 0.2630 | 0.4345 (<0.001) |
Creatine Kinase-MB | 0.0200 | 0 | 0.0344 | 0 | 0 | 0.0087 | 0.2235 (0.002) |
Endothelin-1b | 0 | 0 | 0 | 0 | 0 | 0 | 0.0155 (0.921) |
Eotaxin | −0.1066 | −0.1808 | −0.1291 | −0.2042 | −0.1816 | −0.0717 | −0.1164 (0.099) |
Epidermal Growth Factor | 0 | 0 | 0 | 0 | 0 | 0 | −0.0540 (0.438) |
Epithelial-Derived Neutrophil-Activating Protein-78 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0507 (0.466) |
Erythropoietina | 0 | 0 | 0 | 0 | 0 | 0 | 0.0883 (0.526) |
Extracellular Newly Identified RAGE-Binding Protein | 0 | 0 | 0 | 0 | 0 | 0 | 0.0343 (0.622) |
Fatty Acid Binding Protein | 0 | 0 | 0 | 0 | 0 | 0 | 0.2676 (<0.001) |
Ferritin | 0.1036 | 0.0834 | 0.1068 | 0.1397 | 0.0701 | 0.0988 | 0.3946 (<0.001) |
Fibrinogen | 0 | 0 | 0 | 0 | 0 | 0 | 0.1273 (0.069) |
Fibroblast Growth Factor-Basicb | 0 | 0 | 0.0100 | 0 | 0 | 0 | 0.2341 (0.111) |
Granulocyte Colony-Stimulating Factor | −0.0564 | −0.1372 | −0.0756 | −0.1276 | −0.1268 | −0.0252 | −0.0437 (0.530) |
Granulocyte-Macrophage Colony-Stimulating Factorb | 0.0175 | 0 | 0.0320 | 0 | 0.0604 | 0.0066 | 0.3837 (0.038) |
Growth Hormone | −0.1155 | −0.0898 | −0.1181 | −0.1430 | −0.1529 | −0.1158 | −0.3918 (<0.001) |
Haptoglobin | 0 | 0 | 0 | 0 | 0 | 0 | 0.1949 (0.007) |
Immunoglobulin A | 0 | 0 | 0 | 0 | 0 | 0 | 0.1245 (0.075) |
Immunoglobulin E | 0 | 0 | 0 | 0 | 0 | 0 | 0.1028 (0.142) |
Immunoglobulin M | −0.0883 | −0.1068 | −0.0940 | −0.1568 | −0.0982 | −0.0715 | −0.1486 (0.034) |
Intercellular Adhesion Molecule-1 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0842 (0.229) |
Interferon-Gammaa | 0 | 0 | 0 | 0 | 0 | 0 | −0.0001 (0.999) |
Interleukin-1alphab | 0 | 0 | 0 | 0 | 0 | 0 | −0.1667 (0.257) |
Interleukin-1betaa | 0 | 0 | 0.0022 | 0 | 0 | 0 | 0.1703 (0.222) |
Interleukin-1 Receptor Antagonist | −0.0026 | 0 | −0.0219 | 0 | 0 | 0 | 0.0328 (0.638) |
Interleukin-3b | 0 | 0 | 0 | 0 | 0 | 0 | 0.1162 (0.406) |
Interleukin-4b | 0 | 0 | 0 | 0 | 0 | 0 | −0.1744 (0.219) |
Interleukin-5a | 0 | 0 | 0 | 0 | 0 | 0 | −0.0041 (0.976) |
Interleukin-6a | 0 | 0 | 0 | 0 | 0 | 0 | 0.2417 (0.083) |
Interleukin-7b | 0.0157 | 0 | 0.0348 | 0 | 0 | 0 | 0.2358 (0.092) |
Interleukin-8 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0582 (0.403) |
Interleukin-10b | 0 | 0 | 0 | 0 | 0 | 0 | 0.2179 (0.161) |
Interleukin-12p40b | 0 | 0 | −0.0170 | 0 | 0 | 0 | −0.1583 (0.322) |
Interleukin-13 | −0.0057 | 0 | −0.0236 | 0 | 0 | 0 | −0.0239 (0.732) |
Interleukin-15a | 0 | 0 | 0 | 0 | 0 | 0 | −0.0819 (0.557) |
Interleukin-16 | 0 | −0.0243 | 0 | 0 | 0 | 0 | 0.0790 (0.263) |
Interleukin-18 | 0.0404 | 0.0379 | 0.0588 | 0.0677 | 0.0798 | 0.0223 | 0.2362 (0.001) |
Leptin | 0.3312 | 0.4337 | 0.3499 | 0.4554 | 0.4052 | 0.2861 | 0.3234 (<0.001) |
Lipoprotein (a) | 0 | 0 | 0 | 0 | 0 | 0 | −0.1016 (0.147) |
Macrophage-Derived Chemokine | 0 | 0 | 0 | 0 | 0 | 0 | 0.0860 (0.217) |
Macrophage Inflammatory Protein-1alpha | 0 | 0 | 0 | 0 | 0 | 0 | 0.1323 (0.061) |
Macrophage Inflammatory Protein-1beta | 0 | 0 | 0.0115 | 0 | 0 | 0 | 0.1924 (0.008) |
Matrix Metalloproteinase -2a | 0 | 0 | 0 | 0 | 0 | 0 | 0.1380 (0.322) |
Matrix Metalloproteinase-3 | 0 | 0 | 0 | 0 | 0 | 0 | 0.1560 (0.027) |
Matrix Metalloproteinase-9a | 0 | 0 | 0 | 0 | 0 | 0 | 0.1401 (0.315) |
Monocyte Chemotactic Protein-1 | 0.0283 | 0.0829 | 0.0451 | 0.0572 | 0.0927 | 0.0030 | 0.1757 (0.013) |
Myeloperoxidase | −0.0543 | −0.0728 | −0.0713 | −0.1149 | −0.0469 | −0.0239 | −0.0670 (0.337) |
Myoglobin | 0.2267 | 0.3195 | 0.2286 | 0.2983 | 0.2587 | 0.2115 | 0.4299 (<0.001) |
Plasminogen Activator Inhibitor 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0.2314 (0.001) |
Pregnancy-Associated Plasma Protein a | 0 | 0 | 0 | 0 | 0 | 0 | −0.0279 (0.689) |
Prostatic Acid Phosphatasea | 0 | 0 | 0 | 0 | 0 | 0 | 0.1638 (0.240) |
T-Cell Specific Protein RANTES | 0 | 0 | 0 | 0 | 0 | 0 | 0.1368 (0.052) |
Serum Amyloid P | 0.1028 | 0 | 0.0961 | 0.0668 | 0 | 0.1157 | 0.5657 (<0.001) |
Serum Glutamic Oxaloacetic Transminase | 0.0380 | 0 | 0.0561 | 0.0795 | 0 | 0.0122 | 0.0617 (0.378) |
Sex Hormone Binding Globulin | −0.2827 | −0.3609 | −0.2739 | −0.3612 | −0.2703 | −0.2593 | −0.5321 (<0.001) |
Stem Cell Factor | 0 | 0 | 0 | 0 | 0 | 0 | 0.0931 (0.182) |
Surfactant Protein D | −0.1612 | −0.2086 | −0.1794 | −0.2439 | −0.2401 | −0.1328 | −0.2215 (0.002) |
Thrombopoietin | 0 | 0 | 0 | 0 | 0 | 0 | 0.0924 (0.186) |
Thyroid Stimulating Hormone | −0.0207 | −0.0430 | −0.0379 | −0.0273 | 0 | 0 | −0.0352 (0.613) |
Thyroxine Binding Globulin | 0 | 0 | 0 | 0 | 0 | 0 | −0.0751 (0.285) |
Tissue Factorb | 0 | 0 | 0 | 0 | 0 | 0 | 0.1279 (0.489) |
Tissue Inhibitor of Metalloproteinase 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0.1665 (0.018) |
Tumor Necrosis Factor-alpha | 0 | 0 | 0 | 0 | 0 | 0 | 0.0982 (0.162) |
Tumor Necrosis Factor-betab | 0 | 0 | 0 | 0 | 0 | 0 | −0.0113 (0.941) |
Tumor Necrosis Factor RII | 0 | 0 | 0 | 0 | 0 | 0 | 0.1797 (0.011) |
Vascular Cell Adhesion Molecule-1 | 0.0333 | 0.0473 | 0.0502 | 0.0654 | 0 | 0.0103 | 0.1073 (0.125) |
Vascular Endothelial Growth Factor | 0 | 0 | 0 | 0 | 0 | 0 | 0.1468 (0.036) |
von Willebrand Factor | 0 | 0 | 0.0039 | 0 | 0 | 0 | 0.1308 (0.061) |
YKL-40 | 0.0284 | 0.0278 | 0.0434 | 0.0222 | 0.0654 | 0.0152 | 0.1619 (0.021) |