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Table 13 TESAOD application, overweight and obese subjects combined (N = 463 normal-weight, N = 372 overweight and obese)

From: Least absolute shrinkage and selection operator type methods for the identification of serum biomarkers of overweight and obesity: simulation and application

  Lasso Adaptive LASSO Elastic Net Iterated LASSO Bootstrap-Enhanced LASSO-75 Weighted Fusion Logistic Regression, Coefficient (p-value)
Adiponectin −0.2143 −0.2770 −0.2210 −0.2827 −0.2334 −0.1985 −0.4799 (<0.001)
Alpha-1 Antitrypsin −0.0311 0 −0.0464 0 0 −0.0199 −0.1415 (0.045)
Alpha-Fetoprotein 0 0 0 0 0 0 0.0833 (0.238)
Alpha-2 Macroglobulin −0.0435 0 −0.0580 −0.0276 −0.0705 −0.0348 −0.3158 (<0.001)
Apolipoprotein A-1 −0.0105 −0.0257 −0.0324 0 0 0 −0.0684 (0.328)
Apolipoprotein C-III 0 0 0 0 0 0 0.2077 (0.003)
Apolipoprotein H 0.0759 0.1047 0.0965 0.1028 0.1201 0.0628 0.3683 (<0.001)
Beta-2 Microglobulin 0 0 0 0 0 0 0.1925 (0.007)
Brain Derived Neurotrophic Factor 0 0 0 0 0 0 0.0886 (0.206)
Calcitonina 0.0461 0.0647 0.0657 0.0782 0.1076 0.0236 0.3263 (0.020)
Cancer Antigen 19-9 0 0 0 0 0 0 −0.0265 (0.703)
Cancer Antigen 125 0 0 0 0 0 0 0.0769 (0.272)
Carcinoembryonic Antigen 0 0 0 0 0 0 −0.0118 (0.866)
Soluble CD14 −0.1439 −0.2052 −0.1598 −0.2411 −0.1681 −0.1143 −0.1542 (0.030)
CD40 0 −0.0075 −0.0085 0 0 0 0.0618 (0.376)
CD40Ligand 0 0 0 0 0 0 −0.0206 (0.768)
Club Cell Secretory Protein 0 0 −0.0009 0 0 0 −0.0177 (0.799)
Complement 3 0.1094 0.1174 0.1313 0.1307 0.1337 0.0923 0.4334 (<0.001)
C-Reactive Protein 0.2968 0.4064 0.3015 0.4235 0.3485 0.2630 0.4345 (<0.001)
Creatine Kinase-MB 0.0200 0 0.0344 0 0 0.0087 0.2235 (0.002)
Endothelin-1b 0 0 0 0 0 0 0.0155 (0.921)
Eotaxin −0.1066 −0.1808 −0.1291 −0.2042 −0.1816 −0.0717 −0.1164 (0.099)
Epidermal Growth Factor 0 0 0 0 0 0 −0.0540 (0.438)
Epithelial-Derived Neutrophil-Activating Protein-78 0 0 0 0 0 0 0.0507 (0.466)
Erythropoietina 0 0 0 0 0 0 0.0883 (0.526)
Extracellular Newly Identified RAGE-Binding Protein 0 0 0 0 0 0 0.0343 (0.622)
Fatty Acid Binding Protein 0 0 0 0 0 0 0.2676 (<0.001)
Ferritin 0.1036 0.0834 0.1068 0.1397 0.0701 0.0988 0.3946 (<0.001)
Fibrinogen 0 0 0 0 0 0 0.1273 (0.069)
Fibroblast Growth Factor-Basicb 0 0 0.0100 0 0 0 0.2341 (0.111)
Granulocyte Colony-Stimulating Factor −0.0564 −0.1372 −0.0756 −0.1276 −0.1268 −0.0252 −0.0437 (0.530)
Granulocyte-Macrophage Colony-Stimulating Factorb 0.0175 0 0.0320 0 0.0604 0.0066 0.3837 (0.038)
Growth Hormone −0.1155 −0.0898 −0.1181 −0.1430 −0.1529 −0.1158 −0.3918 (<0.001)
Haptoglobin 0 0 0 0 0 0 0.1949 (0.007)
Immunoglobulin A 0 0 0 0 0 0 0.1245 (0.075)
Immunoglobulin E 0 0 0 0 0 0 0.1028 (0.142)
Immunoglobulin M −0.0883 −0.1068 −0.0940 −0.1568 −0.0982 −0.0715 −0.1486 (0.034)
Intercellular Adhesion Molecule-1 0 0 0 0 0 0 0.0842 (0.229)
Interferon-Gammaa 0 0 0 0 0 0 −0.0001 (0.999)
Interleukin-1alphab 0 0 0 0 0 0 −0.1667 (0.257)
Interleukin-1betaa 0 0 0.0022 0 0 0 0.1703 (0.222)
Interleukin-1 Receptor Antagonist −0.0026 0 −0.0219 0 0 0 0.0328 (0.638)
Interleukin-3b 0 0 0 0 0 0 0.1162 (0.406)
Interleukin-4b 0 0 0 0 0 0 −0.1744 (0.219)
Interleukin-5a 0 0 0 0 0 0 −0.0041 (0.976)
Interleukin-6a 0 0 0 0 0 0 0.2417 (0.083)
Interleukin-7b 0.0157 0 0.0348 0 0 0 0.2358 (0.092)
Interleukin-8 0 0 0 0 0 0 0.0582 (0.403)
Interleukin-10b 0 0 0 0 0 0 0.2179 (0.161)
Interleukin-12p40b 0 0 −0.0170 0 0 0 −0.1583 (0.322)
Interleukin-13 −0.0057 0 −0.0236 0 0 0 −0.0239 (0.732)
Interleukin-15a 0 0 0 0 0 0 −0.0819 (0.557)
Interleukin-16 0 −0.0243 0 0 0 0 0.0790 (0.263)
Interleukin-18 0.0404 0.0379 0.0588 0.0677 0.0798 0.0223 0.2362 (0.001)
Leptin 0.3312 0.4337 0.3499 0.4554 0.4052 0.2861 0.3234 (<0.001)
Lipoprotein (a) 0 0 0 0 0 0 −0.1016 (0.147)
Macrophage-Derived Chemokine 0 0 0 0 0 0 0.0860 (0.217)
Macrophage Inflammatory Protein-1alpha 0 0 0 0 0 0 0.1323 (0.061)
Macrophage Inflammatory Protein-1beta 0 0 0.0115 0 0 0 0.1924 (0.008)
Matrix Metalloproteinase -2a 0 0 0 0 0 0 0.1380 (0.322)
Matrix Metalloproteinase-3 0 0 0 0 0 0 0.1560 (0.027)
Matrix Metalloproteinase-9a 0 0 0 0 0 0 0.1401 (0.315)
Monocyte Chemotactic Protein-1 0.0283 0.0829 0.0451 0.0572 0.0927 0.0030 0.1757 (0.013)
Myeloperoxidase −0.0543 −0.0728 −0.0713 −0.1149 −0.0469 −0.0239 −0.0670 (0.337)
Myoglobin 0.2267 0.3195 0.2286 0.2983 0.2587 0.2115 0.4299 (<0.001)
Plasminogen Activator Inhibitor 1 0 0 0 0 0 0 0.2314 (0.001)
Pregnancy-Associated Plasma Protein a 0 0 0 0 0 0 −0.0279 (0.689)
Prostatic Acid Phosphatasea 0 0 0 0 0 0 0.1638 (0.240)
T-Cell Specific Protein RANTES 0 0 0 0 0 0 0.1368 (0.052)
Serum Amyloid P 0.1028 0 0.0961 0.0668 0 0.1157 0.5657 (<0.001)
Serum Glutamic Oxaloacetic Transminase 0.0380 0 0.0561 0.0795 0 0.0122 0.0617 (0.378)
Sex Hormone Binding Globulin −0.2827 −0.3609 −0.2739 −0.3612 −0.2703 −0.2593 −0.5321 (<0.001)
Stem Cell Factor 0 0 0 0 0 0 0.0931 (0.182)
Surfactant Protein D −0.1612 −0.2086 −0.1794 −0.2439 −0.2401 −0.1328 −0.2215 (0.002)
Thrombopoietin 0 0 0 0 0 0 0.0924 (0.186)
Thyroid Stimulating Hormone −0.0207 −0.0430 −0.0379 −0.0273 0 0 −0.0352 (0.613)
Thyroxine Binding Globulin 0 0 0 0 0 0 −0.0751 (0.285)
Tissue Factorb 0 0 0 0 0 0 0.1279 (0.489)
Tissue Inhibitor of Metalloproteinase 1 0 0 0 0 0 0 0.1665 (0.018)
Tumor Necrosis Factor-alpha 0 0 0 0 0 0 0.0982 (0.162)
Tumor Necrosis Factor-betab 0 0 0 0 0 0 −0.0113 (0.941)
Tumor Necrosis Factor RII 0 0 0 0 0 0 0.1797 (0.011)
Vascular Cell Adhesion Molecule-1 0.0333 0.0473 0.0502 0.0654 0 0.0103 0.1073 (0.125)
Vascular Endothelial Growth Factor 0 0 0 0 0 0 0.1468 (0.036)
von Willebrand Factor 0 0 0.0039 0 0 0 0.1308 (0.061)
YKL-40 0.0284 0.0278 0.0434 0.0222 0.0654 0.0152 0.1619 (0.021)
  1. aCategorized at median; bCategorized at detection limit