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Table 6 TESAOD analysis, coefficients refer to associations of standardized biomarker values with overweight and obese separately

From: Least absolute shrinkage and selection operator type methods for the identification of serum biomarkers of overweight and obesity: simulation and application

  Overweight Obese
(N = 463 normal-weight, N = 306 overweight) (N = 463 normal-weight, N = 66 obese)
LASSO Adaptive LASSO Elastic Net Iterated LASSO Bootstrap-Enhanced LASSO-75 Weighted Fusion p^ LASSO Adaptive LASSO Elastic Net Iterated LASSO Bootstrap-Enhanced LASSO-75 Weighted Fusion p^
Adiponectin −0.2511 −0.3500 −0.2498 −0.3297 −0.3226 −0.2440 ** −0.0101 0 −0.0006 0 0 −0.0853 *
Apolipoprotein H 0.0571 0.0838 0.0762 0.1479 0.1309 0.0512 ** 0.0881 0.1642 0.0346 0 0.2160 0.1277 **
Calcitonina 0.0469 0.0765 0.0668 0.1681 0.0895 0.0352 * 0 0 0 0 0 0.0624  
Soluble CD14 −0.1133 −0.1679 −0.1296 −0.2492 −0.1923 −0.0994 * −0.1020 −0.1706 −0.0488 0 −0.2272 −0.0965  
Complement 3 0.0847 0.1238 0.1183 0.2080 0.1483 0.0767 ** 0.0899 0 0.0761 0 0 0.1306 **
C-Reactive Protein 0.2105 0.3150 0.2188 0.3791 0.2901 0.1923 ** 0.5213 0.7636 0.4765 0.6802 0.6052 0.2526 **
Ferritin 0.1131 0.0969 0.1120 0.1431 0.1055 0.1115 ** 0.0753 0 0.0469 0 0 0.0671 *
Growth Hormone −0.1163 −0.1238 −0.1259 −0.1737 −0.1566 −0.1144 ** 0 0 0 0 0 −0.0888 *
Immunoglobulin M −0.0410 −0.0288 −0.0569 −0.1228 −0.0949 −0.0320 * −0.1014 0 −0.0450 0 0 −0.1120  
Interleukin-18 0.0073 0.0047 0.0348 0.1515 0 0 ** 0.1214 0.0653 0.0804 0.0774 0.2373 0.0870 *
Leptin 0.2057 0.3263 0.2102 0.3690 0.3177 0.1829 ** 0.9186 1.1286 0.8548 1.2502 1.1551 0.3792 **
Monocyte Chemotactic Protein-1 0 0 0 0 0 0   0.1628 0.1471 0.1269 0.1792 0.2546 0.1275 **
Myoglobin 0.2323 0.3468 0.2300 0.3341 0.2856 0.2162 ** 0.0391 0 0.0316 0 0 0.0829 *
Sex Hormone Binding Globulin −0.2130 −0.2033 −0.1979 −0.2220 −0.2046 −0.2009 ** −0.4768 −0.6470 −0.4499 −0.7274 −0.4767 −0.2334 **
Surfactant Protein D −0.1053 −0.1518 −0.1250 −0.2361 −0.2089 −0.0924 * −0.3136 −0.4086 −0.2351 −0.3848 −0.4663 −0.2820 **
von Willebrand Factor 0 0 0 0 0 0   0.1980 0.0683 0.1737 0.2571 0.2694 0.1364 **
YKL-40 0 0 0.0108 0 0 0   0.1095 0.0847 0.0733 0.0314 0.1979 0.1151 **
  1. aCategorized at median; ^: p-value for univariate association from binary logistic regression; *: p < 0.05; **: p < 0.01