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Drug*placebo interaction effect may bias clinical trials interpretation: hybrid balanced placebo and randomized placebo-controlled design

  • Muhammad M. Hammami1, 2Email author,
  • Safa Hammami1,
  • Reem Al-Swayeh1,
  • Eman Al-Gaai1,
  • Faduma Abdi Farah1 and
  • Sophia J. S. De Padua1
BMC Medical Research MethodologyBMC series – open, inclusive and trusted201616:166

https://doi.org/10.1186/s12874-016-0269-1

Received: 18 May 2016

Accepted: 22 November 2016

Published: 29 November 2016

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Open Peer Review reports

Pre-publication versions of this article are available by contacting info@biomedcentral.com.

Original Submission
18 May 2016 Submitted Original manuscript
Author responded Author comments
Reviewed Reviewer Report
Resubmission - Version 2
Submitted Manuscript version 2
Author responded Author comments
Reviewed Reviewer Report
Resubmission - Version 3
Submitted Manuscript version 3
Publishing
22 Nov 2016 Editorially accepted
29 Nov 2016 Article published 10.1186/s12874-016-0269-1

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article are available by contacting info@biomedcentral.com.

You can find further information about the peer review system here.

Authors’ Affiliations

(1)
Department of Clinical Studies and Empirical Ethics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
(2)
Alfaisal University College of Medicine, Riyadh, Saudi Arabia

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