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Fig. 1 | BMC Medical Research Methodology

Fig. 1

From: Test-treatment RCTs are susceptible to bias: a review of the methodological quality of randomized trials that evaluate diagnostic tests

Fig. 1

Example of a replacement test-treatment RCT. Patients randomized to the experimental arm receive a test for the presence of Helicobacter pylori, which is eradicated if found, while patients without bacterial infection are given proton pump inhibitors (acid suppression). Patients randomized to the control arm receive no test and are all given proton pump inhibitors (acid suppression), reflecting standard care. The outcome of the trial is eradication of dyspeptic symptoms at 12 months [16]

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BMC Medical Research Methodology

ISSN: 1471-2288

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