Skip to main content

Table 1 Showing the level of cumulated type 1-error risk, if a threshold of 5% is applied constantly at each sequential significance testing, on an accumulating number of trial participants

From: Trial Sequential Analysis in systematic reviews with meta-analysis

Number of statistical significance tests

The cumulated type 1-error risk in %

1

5%

2

8%

5

14%

20

25%

100

37%

Infinitely many

100%

  1. The resulting type 1-error risk will be larger than the nominal 5%, if a decisison is made to stop the inclusion of participants when P <0.05 and to continue when P ≥0.05 [22, 24]