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Table 3 Results of meta-analyses with and without unpublished studies

From: Grey literature in systematic reviews: a cross-sectional study of the contribution of non-English reports, unpublished studies and dissertations to the results of meta-analyses in child-relevant reviews

  Number of studies Number of participants Pooled estimate (95% CI)
Summary measure
% change in effect size/CI width Difference in estimates
Review With unpublished Without unpublished % lost With unpublished Without unpublished % lost With unpublished Without unpublished   
Acute respiratory infections
 Corticosteroids for acute bacterial meningitis (CD004405) 25 24 4.0 4121 4036 2.1 0.90 (0.80, 1.01)
RR
0.90 (0.80, 1.01) 0/0 Negligible
 Vitamin C for preventing and treating the common cold (CD000980) 29 27 6.9 11306 11244 0.5 0.95 (0.92, 0.98)
RR
0.95 (0.93, 0.98) 0/16.7 Negligible
 Neuraminidase inhibitors for preventing and treating influenza in children (CD002744) 2 1 50.0 585 346 40.9 −0.13 (−0.21, −0.05)
RD
−0.16 (−0.26, −0.05) 23.1/31.3 Large
 Bronchodilators for bronchiolitis (CD001266) 24 22 8.3 1182 1113 5.8 −0.45 (−0.96, 0.05)
MD
−0.29 (−0.79, 0.21) 35.6/1.0 Large
 Neuraminidase inhibitors for preventing and treating influenza (CD008965) 5 0 100 3713 0 100 −21.29 (−29.59, −12.98)
MD
NA NA -
Infectious diseases
 Artesunate versus quinine for treating severe malaria (CD005967) 8 6 25.0 7429 7198 3.1 0.71 (0.62, 0.80)
RR
0.72 (0.64, 0.82) 1.4/0.0 Negligible
 Probiotics for treating acute infectious diarrhoea (CD003048) 35 34 2.9 4555 4461 2.1 −24.76 (−33.61, −15.91)
MD
−23.91 (−32.78, −15.03) 3.4/3.5 Negligible
Developmental, psychosocial and learning problems
 Iron therapy for improving psychomotor development and cognitive function in children under the age of three with iron deficiency anaemia (CD001444) 5 4 20.0 162 128 21.0 −1.25 (−4.56, 2.06)
MD
−1.96 (−5.17, 3.15) 56.8/25.7 Large