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Fig. 5 | BMC Medical Research Methodology

Fig. 5

From: A DAG-based comparison of interventional effect underestimation between composite endpoint and multi-state analysis in cardiovascular trials

Fig. 5

Mean hazard ratio estimates in the simulation model under λ 1=0.14,λ 2=1.17, ρ=1, a common treatment effect on non-fatal and fatal outcomes (β 1=β 2= log(0.75)) and varying influence of an unobserved variable Z (having variance θ). Cox proportional hazards analysis for the composite and the single components, respectively (1st events), Andersen-Gill analysis (all events, composite outcome) and multi-state analysis (all events, fatal and non-fatal outcomes)

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