Fig. 7
Mean hazard ratio estimates in the simulation model under λ 1=0.14,λ 2=1.17,θ=0, a common direct treatment effect on non-fatal and fatal outcomes (β 1=β 2= log(0.75)) and transition hazards that increase by a factor of ρ after each non-fatal event. Cox proportional hazards analysis for the composite and the single components, respectively (1st events), Andersen-Gill analysis (all events, composite outcome) and multi-state analysis (all events, fatal and non-fatal outcomes)