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Table 2 Expected patient numbers in the discrete failure time example for time to death stratified by previously experienced non-fatal event (“Direct effect bias”section)

From: A DAG-based comparison of interventional effect underestimation between composite endpoint and multi-state analysis in cardiovascular trials

Stratum

Group

Death at t 2

Alive at t 2

At risk

OR

Non-fatal event at t 1

Treatment

120

180

300

1

 

Placebo

240

360

600

 

No non-fatal event at t 1

Treatment

120

480

600

1

 

Placebo

60

240

300

 

All patients (unstratified)

Treatment

240

660

900

0.73

 

Placebo

300

600

900

 
  1. Odds Ratio (OR) for mortality under treatment as compared to control