A DAG-based comparison of interventional effect underestimation between composite endpoint and multi-state analysis in cardiovascular trials

Jahn-Eimermacher, Antje; Ingel, Katharina; Preussler, Stella; Bayes-Genis, Antoni; Binder, Harald

doi:10.1186/s12874-017-0366-9

Table 4 Simulation results for λ ₁=0.655 and λ ₂=0.655

From: A DAG-based comparison of interventional effect underestimation between composite endpoint and multi-state analysis in cardiovascular trials

Simulation parameters				Results of 1st-event-analyses						Results of all-events-analyses
exp(β ₁)	exp(β ₂)	θ	ρ	\(\exp (\widehat {\beta _{CE}})\)	\(\widehat {SE}(\beta _{CE})\)	\(\exp (\widehat {\beta _{1}})\)	\(\widehat {SE}(\beta _{1})\)	\(\exp (\widehat {\beta _{2}})\)	\(\widehat {SE}(\beta _{2})\)	\(\exp (\widehat {\beta _{CE}})\)	\(\widehat {SE}(\beta _{CE})\)	\(\exp (\widehat {\beta _{1}})\)	\(\widehat {SE}(\beta _{1})\)	\(\exp (\widehat {\beta _{2}})\)	\(\widehat {SE}(\beta _{2})\)
0.75	0.75	0.00	1.00	0.75	0.12	0.75	0.17	0.75	0.16	0.75	0.10	0.75	0.14	0.75	0.14
0.75	0.75	0.00	1.05	0.75	0.11	0.75	0.16	0.75	0.16	0.74	0.10	0.75	0.14	0.74	0.14
0.75	0.75	0.00	1.10	0.75	0.11	0.75	0.16	0.75	0.16	0.74	0.10	0.74	0.14	0.74	0.14
0.75	0.75	0.00	1.15	0.75	0.12	0.75	0.17	0.75	0.16	0.74	0.10	0.74	0.14	0.74	0.14
0.75	0.75	0.00	1.20	0.75	0.12	0.75	0.16	0.75	0.16	0.73	0.10	0.74	0.13	0.73	0.14
0.75	0.75	0.00	1.25	0.75	0.12	0.75	0.17	0.75	0.16	0.73	0.10	0.73	0.14	0.73	0.15
0.75	0.75	0.00	1.30	0.75	0.12	0.75	0.16	0.75	0.17	0.73	0.11	0.73	0.13	0.72	0.15
0.75	0.75	0.60	1.00	0.80	0.12	0.80	0.18	0.80	0.18	0.78	0.12	0.78	0.15	0.78	0.17
0.75	0.75	0.60	1.05	0.80	0.12	0.80	0.18	0.80	0.18	0.78	0.12	0.78	0.15	0.78	0.18
0.75	0.75	0.60	1.10	0.80	0.12	0.80	0.18	0.80	0.18	0.78	0.12	0.78	0.14	0.78	0.17
0.75	0.75	0.60	1.15	0.80	0.12	0.80	0.18	0.80	0.18	0.78	0.12	0.78	0.15	0.78	0.18
0.75	0.75	0.60	1.20	0.80	0.12	0.81	0.18	0.80	0.18	0.78	0.13	0.78	0.14	0.78	0.18
0.75	0.75	0.60	1.25	0.80	0.13	0.80	0.18	0.80	0.18	0.78	0.13	0.78	0.15	0.78	0.18
0.75	0.75	0.60	1.30	0.80	0.13	0.80	0.18	0.80	0.18	0.78	0.13	0.78	0.14	0.78	0.18
0.92	0.75	0.00	1.00	0.84	0.11	0.92	0.16	0.75	0.17	0.83	0.10	0.92	0.13	0.75	0.14
0.92	0.75	0.00	1.05	0.83	0.12	0.92	0.16	0.75	0.17	0.83	0.10	0.91	0.13	0.75	0.14
0.92	0.75	0.00	1.10	0.84	0.11	0.92	0.16	0.75	0.16	0.83	0.10	0.91	0.13	0.74	0.14
0.92	0.75	0.00	1.15	0.84	0.12	0.92	0.16	0.75	0.17	0.82	0.10	0.90	0.13	0.74	0.15
0.92	0.75	0.00	1.20	0.83	0.11	0.92	0.16	0.75	0.17	0.82	0.10	0.90	0.13	0.73	0.15
0.92	0.75	0.00	1.25	0.83	0.12	0.92	0.16	0.75	0.17	0.81	0.10	0.89	0.13	0.73	0.15
0.92	0.75	0.00	1.30	0.83	0.11	0.92	0.16	0.75	0.17	0.81	0.10	0.89	0.13	0.72	0.15
0.92	0.75	0.60	1.00	0.87	0.12	0.95	0.17	0.78	0.18	0.84	0.12	0.93	0.14	0.76	0.17
0.92	0.75	0.60	1.05	0.87	0.12	0.97	0.17	0.78	0.18	0.84	0.12	0.93	0.14	0.76	0.18
0.92	0.75	0.60	1.10	0.87	0.12	0.96	0.17	0.78	0.18	0.84	0.12	0.93	0.14	0.75	0.18
0.92	0.75	0.60	1.15	0.87	0.12	0.96	0.17	0.78	0.18	0.84	0.12	0.92	0.14	0.75	0.18
0.92	0.75	0.60	1.20	0.87	0.12	0.96	0.17	0.78	0.18	0.83	0.12	0.92	0.14	0.75	0.18
0.92	0.75	0.60	1.25	0.87	0.12	0.96	0.17	0.78	0.18	0.83	0.13	0.91	0.14	0.75	0.19
0.92	0.75	0.60	1.30	0.87	0.12	0.96	0.17	0.78	0.18	0.83	0.13	0.91	0.14	0.74	0.18

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