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Table 3 Estimated calibration in the validation set (observed:expected (O:E) ratio) across fifteen different simulated scenarios

From: Accounting for treatment use when validating a prognostic model: a simulation study

Scenario

Method

 

Reference: untreated

Ignore treatment

Exclude treated

IPW

IPW, exclude

IPWtrunc exclude

1

1.00 (0.09)

0.76 (0.07)

1.01 (0.13)

0.79 (0.09)

1.00 (0.13)

1.00 (0.12)

2

1.00 (0.09)

0.79 (0.07)

1.00 (0.11)

0.79 (0.07)

1.00 (0.11)

1.00 (0.11)

3

1.01 (0.09)

0.69 (0.07)

1.00 (0.13)

0.76 (0.09)

1.00 (0.13)

1.00 (0.12)

4

1.00 (0.09)

0.72 (0.07)

1.01 (0.16)

0.74 (0.30)

0.98 (0.44)

1.00 (0.17)

5

1.00 (0.09)

0.80 (0.08)

1.00 (0.13)

0.68 (0.07)

1.00 (0.10)

1.00 (0.10)

6

1.00 (0.09)

0.87 (0.08)

1.01 (0.10)

0.79 (0.08)

1.00 (0.10)

1.00 (0.10)

7

1.00 (0.09)

0.96 (0.09)

1.01 (0.10)

0.93 (0.10)

1.00 (0.10)

1.00 (0.10)

8

1.00 (0.09)

0.63 (0.06)

1.01 (0.12)

0.68 (0.08)

1.00 (0.13)

1.00 (0.12)

9

1.00 (0.09)

0.91 (0.08)

1.01 (0.12)

0.92 (0.09)

1.00 (0.13)

1.00 (0.12)

10

1.00 (0.09)

0.49 (0.06)

1.00 (0.17)

0.68 (0.11)

1.00 (0.20)

1.00 (0.18)

11

1.00 (0.09)

0.66 (0.07)

1.00 (0.17)

0.79 (0.11)

1.00 (0.20)

1.00 (0.18)

12

1.01 (0.09)

0.88 (0.08)

1.01 (0.17)

0.92 (0.12)

1.00 (0.20)

1.00 (0.18)

13

1.00 (0.09)

0.75 (0.07)

0.90 (0.12)

0.76 (0.08)

0.87 (0.12)

0.88 (0.11)

14

1.00 (0.09)

0.74 (0.07)

0.70 (0.10)

0.72 (0.07)

0.67 (0.10)

0.67 (0.09)

15

1.00 (0.09)

0.76 (0.07)

0.39 (0.07)

0.74 (0.07)

0.38 (0.07)

0.38 (0.07)

  1. Abbreviations: Exclude: exclusion of treated individuals from the analysis; IPW inverse (treatment) probability weighting; IPW trunc IPW with weight truncation at 98th percentile