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Table 4 Estimated discrimination in the validation set (c-index) across fifteen different simulated scenarios

From: Accounting for treatment use when validating a prognostic model: a simulation study

Scenario

Method

 

Reference: untreated

Ignore treatment

Exclude treated

IPW

IPW, exclude

IPWtrunc exclude

1

0.67 (0.02)

0.63 (0.02)

0.65 (0.03)

0.66 (0.03)

0.66 (0.05)

0.65 (0.04)

2

0.67 (0.02)

0.66 (0.02)

0.67 (0.03)

0.66 (0.02)

0.67 (0.03)

0.67 (0.03)

3

0.67 (0.02)

0.59 (0.03)

0.65 (0.03)

0.64 (0.03)

0.66 (0.05)

0.65 (0.04)

4

0.67 (0.02)

0.59 (0.03)

0.60 (0.04)

0.59 (0.08)

0.57 (0.15)

0.60 (0.05)

5

0.67 (0.02)

0.62 (0.02)

0.65 (0.03)

0.66 (0.03)

0.67 (0.03)

0.66 (0.03)

6

0.67 (0.02)

0.64 (0.02)

0.65 (0.03)

0.66 (0.03)

0.66 (0.03)

0.66 (0.03)

7

0.67 (0.02)

0.66 (0.02)

0.65 (0.03)

0.67 (0.03)

0.67 (0.03)

0.66 (0.03)

8

0.67 (0.02)

0.60 (0.03)

0.65 (0.03)

0.66 (0.03)

0.66 (0.05)

0.65 (0.04)

9

0.67 (0.02)

0.65 (0.02)

0.65 (0.03)

0.66 (0.03)

0.66 (0.05)

0.65 (0.04)

10

0.67 (0.02)

0.61 (0.03)

0.65 (0.05)

0.66 (0.05)

0.66 (0.08)

0.65 (0.06)

11

0.67 (0.02)

0.64 (0.03)

0.65 (0.05)

0.66 (0.05)

0.66 (0.08)

0.65 (0.06)

12

0.67 (0.02)

0.66 (0.02)

0.65 (0.05)

0.66 (0.04)

0.66 (0.08)

0.65 (0.06)

13

0.66 (0.02)

0.63 (0.02)

0.63 (0.03)

0.65 (0.03)

0.64 (0.05)

0.63 (0.04)

14

0.65 (0.02)

0.63 (0.02)

0.60 (0.04)

0.62 (0.03)

0.61 (0.04)

0.60 (0.04)

15

0.62 (0.02)

0.61 (0.03)

0.57 (0.05)

0.58 (0.03)

0.57 (0.05)

0.57 (0.05)

  1. Abbreviations: Exclude: exclusion of treated individuals from the analysis; IPW inverse (treatment) probability weighting; IPW trunc IPW with weight truncation at 98th percentile